. Author manuscript; available in PMC: 2022 Jan 31.

Published in final edited form as: Pract Radiat Oncol. 2020 May 18;10(4):220–234. doi: 10.1016/j.prro.2020.04.002

Table 3.

Recommendations for definitive RT with and without systemic therapy and hysterectomy after RT

KQ2 Recommendations	Strength of Recommendation	Quality of Evidence (Refs)
1. For women with FIGO stage IB3-IVA^* squamous cell or adenocarcinoma of the cervix, RT with concurrent platinum-based chemotherapy is recommended for definitive treatment. Implementation remark: Recommended dose for cisplatin is 40 mg/m² weekly for 5–6 cycles.	Strong	High ^8,11−18
2. For women with FIGO stage IB3-IVA cervical cancer, a planned adjuvant hysterectomy after RT or chemoradiation is not recommended.^†	Strong	High ^13,19−21
3. In women with FIGO stage IA1-IB2 that are deemed medically inoperable, RT with or without chemotherapy is conditionally recommended.	Conditional	Expert Opinion

Abbreviation: FIGO = International Federation of Gynecology and Obstetrics; RT = radiation therapy.

Stage IIA1 cancers may be managed with radical hysterectomy in well-selected (eg, nonbulky, with limited vaginal involvement) cases.

^†

In the setting of biopsy-proven gross residual disease after point-A–based dose specification for brachytherapy, surgery may be an option.