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. Author manuscript; available in PMC: 2022 Jan 31.
Published in final edited form as: Endocr Relat Cancer. 2020 Sep;27(9):483–494. doi: 10.1530/ERC-20-0149

Figure 3.

Figure 3

High-impact germline mutations of the CDC73 gene, but not low-impact ones, were associated with an increased risk of parathyroid cancer. (A, B) Comparison of mutation composition between the subjects with parathyroid carcinoma and all other subjects in the Discovery Cohort (A) and Validation cohort (B). (C, D) Kaplan-Meier plots of event-free survival of parathyroid carcinoma in the subjects of the Discovery cohort (c) and the Validation cohort (D) grouped by predicted impact of the CDC73 germline mutations. (E, F) Kaplan-Meier plots of event-free survival of hyperparathyroidism in the subjects of the Discovery cohort (E) and the Validation cohort (F) grouped by predicted impact of the CDC73 germline mutations.