Skip to main content
. Author manuscript; available in PMC: 2022 Jan 31.
Published in final edited form as: Endocr Relat Cancer. 2020 Sep;27(9):483–494. doi: 10.1530/ERC-20-0149

Figure 4.

Figure 4

Germline CDC73 mutations that impact the CTD of parafibromin are associated with an increased risk of parathyroid carcinoma. (A, B) Mapping of high-impact and low-impact CDC73 germline mutations from the present study (A) or in the ExAC database (B) in the coding regions of the CDC73 gene. The gross-indel mutations were not included in this analysis because these genomic alterations affect multiple exons of the CDC73 gene. The Y axis represents the case number in each exon of the CDC73 gene divided by length of the corresponding exon and then multiplied by 100. (C, D) Kaplan–Meier plots of event-free survival of parathyroid carcinoma (c) and hyperparathyroidism (d) in the subjects with germline mutations that are predicted to impact the NTD only (N), the CTD only (C) or both the NTD and CTD (N + C) of parafibromin.