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. 2022 Jan 29;20:51. doi: 10.1186/s12967-022-03257-2

Fig. 11.

Fig. 11

piRNA-14633 promotes CC progression by way of m6A RNA methylation. piRNA-14633 is overexpressed in cervical cancer. piRNA-14633 interactes with 3’UTR of METTL14 to increase METTL14 mRNA stability and promoted the methylase activity of METTL14 promoting the m6 A methylation levels of the downstream target (CYP1B1) and subsequently enhanced expression of CYP1B1, thereby contributed to tumorigenesis of CC