Table 8.
Toxicity report carried out using ProTox-II and STopTox server for top ligand compounds
| S. no | Ligand name | ProTox-II | STopTox | ||||
|---|---|---|---|---|---|---|---|
| predicted LD50 (mg/kg) | Toxicity class | Acute inhalation Toxicity | Acute dermal toxicity | Eye irritation and corrosion | Skin sensitisation | ||
| 1 | 12,28-Oxamanzamine A | 4 | 1 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 2 | Parsiguine | 850 | 4 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Sensitizer (+) |
| 3 | Haliclonacyclamine B | 652 | 4 | Toxic (+) | Toxic (+) | Toxic (+) | Sensitizer (+) |
| 4 | Vialinin B | 5000 | 5 | Non-toxic (−) | Toxic (+) | Non-toxic (−) | Sensitizer (+) |
| 5 | 6-Deoxymanzamine X | 4 | 1 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 6 | Natamycin | 1500 | 4 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 7 | Olorofim | 1420 | 4 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 8 | Deoxytopsentin | 1264 | 4 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Non-sensitizer (−) |
| 9 | Manzamine E | 9 | 2 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 10 | Fascioquinol A | 2000 | 4 | Toxic (+) | Non-toxic (−) | Non-toxic (−) | Non-sensitizer (−) |
| 11 | Pramiconazole | 320 | 4 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 12 | Fascioquinol D | 5000 | 5 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Sensitizer (+) |
| 13 | Saperconazole | 4000 | 5 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 14 | Nakadomarin A | 1000 | 4 | Toxic (+) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 15 | Plakinamine A | 1000 | 4 | Toxic (+) | Toxic (+) | Non-toxic (−) | Non-sensitizer (−) |
| 16 | Fascioquinol C | 1743 | 4 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Sensitizer (+) |
| 17 | Hesperidin | 12,000 | 6 | Non-toxic (−) | Toxic (+) | Non-toxic (−) | Non- Sensitizer (−) |
| 18 | Epoxyazadiradione | 555 | 5 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Non- Sensitizer (−) |
| 19 | Manzamine A | 4 | 1 | Non-toxic (−) | Non-toxic (−) | Toxic (+) | Non-sensitizer (−) |
| 20 | Halicyclamine A | 460 | 4 | Toxic (+) | Toxic (+) | Toxic (+) | Sensitizer (+) |
| 21 | Tetrahydrohaliclonacyclamine A | 194 | 3 | Toxic (+) | Toxic (+) | Toxic (+) | Sensitizer (+) |
| 22 | Phaeosphenone | 221 | 3 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Non-sensitizer (−) |
| 23 | Goniodomin A | 500 | 4 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Non-sensitizer (−) |
| 24 | Stelletin A | 800 | 4 | Non-toxic (−) | Non-toxic (−) | Non-toxic (−) | Sensitizer (+) |