Table 5. Kinetic Solubility and PAMPA Assay Results.

compound	kinetic solubility (μM)	Pe (cm/s)
3	171.0	3.89 × 10–7
4	190.1	5.08 × 10–6
5	33.2	<LOQa
6	4.7	<LOQa
7	40.3	3.73 × 10–6
8	174.6	2.39 × 10–6
9	159.0	1.30 × 10–6
10	195.2	1.51 × 10–6
11	118.7	7.09 × 10–7
12	167.7	<LOQa
13	20.0	<LOQa
14	173.6	5.61 × 10–7
15	176.9	6.23 × 10–8
16	147.0	<LOQa
17	169.3	8.24 × 10–8
18	135.6	8.85 × 10–7
19	176.5	4.56 × 10–7
20	199.7	1.66 × 10–7
21	85.6	2.60 × 10–6
22	164.0	5.97 × 10–7
MRT67307	164.6	2.60 × 10–6
BX-912	155.5	1.39 × 10–7
GSK8612	173.1	<LOQa

^a<LOQ: Below limit of quantitation.