Table 3:

Immunohistochemistry Markers

IHC Marker	Time point	Sig Improvement On Bone Scan Mean (Std)	Imp/Stable/Prog On Bone Scan Mean (Std)	p-value
cMet	Baseline	132.0 (113.9) N=5	99.3 (98.9) N=7	0.61
	Week 6	110.0 (104.3) N=6	91.3 (89.2) N=8	0.71
	Difference	−2.0 (114.5) N=5	5 (98.0) N=7	0.91
pcMet	Baseline	125.0 (95.7) N=5	156.7 (102.9) N=6	0.29
	Week 6	156.7 (102.9) N=6	136.3 (68.2) N=8	0.66
	Difference	31.0 (109.3) N=5	−35.7 (85.0) N=7	0.26
pcMet/cMet	Baseline	5.3 (8.9) N=5	42.3 (88.9) N=7	0.32
	Week 6	4.7 (6.1) N=6	13.1 (24.0) N=8	0.37
	Difference	−2.9 (6.1) N=5	−37.4 (82.0) N=7	0.31
VEGFR2	Baseline	104.0 (65.4) N=5	86.7 (65.3) N=6	0.67
	Week 6	146.7 (56.1) N=6	51.3 (56.7) N=8	0.0009
	Difference	32.0 (95.5) N=5	−30.0 (80.0) N=6	0.27

N=number of patients with tumor in specimen at given timepoint with staining by IHC