TABLE 1.
Description | Gene markers | Cor | p-Value | P Star |
---|---|---|---|---|
CD8+ T cell | CD8A | 0.203398 | 8.22E-05 | ** |
CD8B | 0.200194 | 0.000103 | ** | |
T cell (general) | CD3D | 0.262876 | 3.09E-07 | ** |
CD3E | 0.175419 | 0.000701 | ** | |
B cell | CD19 | 0.286148 | 2.01E-08 | ** |
CD79A | 0.154896 | 0.002776 | ** | |
Monocyte | CD86 | 0.265267 | 2.40E-07 | ** |
CD115 (CSF1R) | 0.132829 | 0.010477 | * | |
TAM | CCL2 | 0.039289 | 0.450371 | |
CD68 | 0.197832 | 0.000129 | ** | |
M1 | ||||
Macrophage | INOS (NOS2) | −0.0387 | 0.457349 | |
IRF5 | 0.434875 | 0 | ** | |
COX2 (PTGS2) | 0.041373 | 0.426875 | ||
M2 | ||||
Macrophage | CD163 | 0.04255 | 0.413647 | |
VSIG4 | 0.053858 | 0.300694 | ||
MS4A4A | 0.050356 | 0.333247 | ||
CD66b | ||||
Neutrophils | (CEACAM8) | 0.154884 | 0.002778 | ** |
CD11b (ITGAM) | 0.252297 | 9.28E-07 | ** | |
CCR7 | 0.043555 | 0.402704 | ||
Natural killer cell | KIR2DL1 | −0.00925 | 0.859044 | |
KIR2DL3 | 0.122901 | 0.017873 | * | |
KIR2DL4 | 0.215475 | 2.84E-05 | ** | |
KIR3DL1 | 0.050247 | 0.334464 | ||
KIR3DL2 | 0.171911 | 0.000885 | ** | |
KIR3DL3 | 0.094199 | 0.069939 | ||
KIR2DS4 | 0.044908 | 0.388409 | ||
Dendritic cell | HLA-DPB1 | 0.169081 | 0.001094 | ** |
HLA-DQB1 | 0.162709 | 0.001684 | ** | |
HLA-DRA | 0.152419 | 0.003278 | ** | |
HLA-DPA1 | 0.112032 | 0.03102 | * | |
BDCA-1 (CD1C) | 0.118305 | 0.022664 | * | |
BDCA-4 (NRP1) | 0.200391 | 0.000105 | ** | |
CD11c (ITGAX) | 0.279898 | 4.78E-08 | ** | |
Th1 | T-bet (TBX21) | 0.063403 | 0.222987 | |
STAT4 | 0.233002 | 6.11E-06 | ** | |
STAT1 | 0.364553 | 5.76E-13 | ** | |
IFN-γ (IFNG) | 0.275613 | 6.83E-08 | ** | |
TNF-α (TNF) | 0.222424 | 1.53E-05 | ** | |
Th2 | GATA3 | 0.152103 | 0.003344 | ** |
STAT6 | 0.132692 | 0.010557 | * | |
STAT5A | 0.274166 | 9.09E-08 | ** | |
IL13 | 0.121788 | 0.018944 | * | |
Tfh | BCL6 | 0.169588 | 0.001056 | ** |
IL21 | 0.192633 | 0.000189 | ** | |
Th17 | STAT3 | 0.087206 | 0.093487 | |
IL17A | 0.084484 | 0.104228 | ||
Treg | FOXP3 | 0.137818 | 0.007895 | ** |
CCR8 | 0.339772 | 1.77E-11 | ** | |
STAT5B | 0.302215 | 3.41E-09 | ** | |
TGFβ (TGFB1) | 0.268872 | 1.62E-07 | ** | |
T-cell exhaustion | PD-1 (PDCD1) | 0.329187 | 7.96E-11 | ** |
CTLA4 | 0.316216 | 4.64E-10 | ** | |
LAG3 | 0.318865 | 4.10E-10 | ** | |
TIM-3 (HAVCR2) | 0.264626 | 2.57E-07 | ** | |
GZMB | 0.102434 | 0.048696 | * |
Cor, R-value of Spearman’s correlation; TAM, tumor-associated macrophage
*p < 0.05; **p < 0.01.