Table 3.
Multivariable Mendelian randomization for age at first sex with risk of oropharyngeal cancer
| Exposure | Exposure dataset | N SNPs | Conditional F-stat |
Q-stat | P value for instrument validity | Method | AFS OR |
95% CI | P |
|---|---|---|---|---|---|---|---|---|---|
| Number of sexual partners | UK Biobank [26] | 152 | 7.81 | 214.14 | 3.77 × 10-4 | IVW | 0.42 | 0.19, 0.94 | 0.04 |
| MR-Egger | 0.24 | 0.06, 1.01 | 0.05 | ||||||
| Comprehensive Smoking Index | UK Biobank [53] | 174 | 8.87 | 191.26 | 0.14 | IVW | 0.48 | 0.25, 0.95 | 0.03 |
| MR-Egger | 0.71 | 0.23, 2.19 | 0.56 | ||||||
| Smoking initiation | GSCAN [51] | 215 | 6.43 | 250.58 | 0.04 | IVW | 0.42 | 0.21, 0.83 | 0.01 |
| MR-Egger | 0.61 | 0.21, 1.74 | 0.35 | ||||||
| Drinks per week | GSCAN [51] | 147 | 28.88 | 164.77 | 0.11 | IVW | 0.72 | 0.43, 1.20 | 0.21 |
| MR-Egger | 0.43 | 0.14 | 1.28 | ||||||
| Risk tolerance | UK Biobank [26] | 160 | 13.68 | 171.18 | 0.21 | IVW | 0.53 | 0.30, 0.93 | 0.03 |
| MR-Egger | 0.24 | 0.08, 0.72 | 0.01 | ||||||
| Educational attainment | SSAGC and UK Biobank [52] | 317 | 7.91 | 319.62 | 0.28 | IVW | 0.74 | 0.39, 1.43 | 0.37 |
| MR-Egger | 0.79 | 0.33, 1.86 | 0.59 | ||||||
Abbreviations: IVW, inverse variance weighted; AFS, age at first sex; OR, odds ratio; CI, confidence intervals; P p value; Q-stat, Cochran’s Q statistic; F-stat, conditional F-statistic; Social Science Genetic Association Consortium (SSGAC). AFS OR represents the odds ratio of oropharyngeal squamous cell carcinoma per SD change (7.3-month delay) in age at first sex