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. 2022 Jan 31;17:29. doi: 10.1186/s13023-021-02068-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Proteomic studies: A Scheme of the workflow. B Volcano plot displaying fold of changes of dysregulated (up- and down-regulations) proteins. C List of up- and downregulate proteins. D List of biological processes affected by up- and down-regulation of the different protein classes. E Proteomaps-based in silico analysis of cellular functions affected by the respective dysregulated proteins. F STRING-based analysis of functional interaction of dysregulated proteins

Fig. 2 — Proteomic studies: A Scheme of the workflow. B Volcano plot displaying fold of changes of dysregulated (up- and down-regulations) proteins. C List of up- and downregulate proteins. D List of biological processes affected by up- and down-regulation of the different protein classes. E Proteomaps-based in silico analysis of cellular functions affected by the respective dysregulated proteins. F STRING-based analysis of functional interaction of dysregulated proteins