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. 2022 Jan 31;41:44. doi: 10.1186/s13046-022-02252-1

Fig. 5.

Fig. 5

The shifting glycolysis to OXPHOS by TRPM7 silencing is abrogated or mitigated by HIF-1α over-expression or AMPK inhibition in ovarian cancer cells. HIF-1α over-expression abrogated the TRPM7 silencing-promoted glycolysis in ovarian cancer cells, determined by the glucose uptake (A), lactic acid production (B) and ECAR (C). Treatment with CC (20 μM) to inhibit AMPK activation mitigated the TRPM7 silencing-induced OXPHOS in ovarian cancer cells, determined by the ATP levels (D), ROS levels (E), NAD+/NAPH ratios (F) and OCR (G)