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. 2022 Jan 31;13:44. doi: 10.1186/s13287-021-02675-1

Fig. 7.

Fig. 7

A proposed mechanistic loop of IL-6 mediated cardiac repair. Injection of WT1-expressing ADSC (eGFP:WT1 ADSC) into the damaged ventricular wall (myocardial infarction) led to an abundant production of interstitial IL-6 which subsequently activated its downstream nuclear target, STAT3, via IL-6/gp130 interaction on cell membrane. Activation of STAT3 in cardiomyocytes commenced a dedifferential process which warranted cardiac proliferation and regeneration of de novo cardiomyocytes for cardiac repair