Table 2.
Multivariable adjusted hazard ratios for all-cause and cause-specific mortality by LDL-C levels in MJ cohort.
| No. of cases | LDL-C levels (mg/dL) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <100 | <70 | 70–99 | 100–109 | 110–129 | 130–159 | 160–179 | ≥180 | ||||||||||
| n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | ||
| All-cause mortality | 11,787 | 2,521 | 1.30* (1.23–1.38) | 461 | 1.72* (1.54–1.92) | 2,060 | 1.24* (1.16–1.32) | 1,192 | 1.11* (1.03–1.20) | 2,639 | ref | 3,193 | 0.97 (0.91–1.02) | 1,163 | 0.96 (0.89–1.04) | 1,079 | 1.13* (1.04–1.22) |
| CVD | 2,236 | 357 | 1.16* (1.00–1.35) | 66 | 1.64* (1.24–2.17) | 291 | 1.09 (0.92–1.28) | 200 | 1.11 (0.92–1.33) | 447 | ref | 686 | 1.18* (1.03–1.34) | 241 | 1.16 (0.98–1.38) | 305 | 1.80* (1.53–2.11) |
| CHD | 614 | 71 | 0.81 (0.59–1.12) | 14 | 1.14 (0.61–2.12) | 57 | 0.76 (0.54–1.08) | 49 | 1.01 (0.71–1.45) | 120 | ref | 187 | 1.24 (0.97–1.59) | 78 | 1.48* (1.09–2.01) | 109 | 2.54* (1.92–3.37) |
| Ischemic stroke | 553 | 79 | 0.94 (0.69–1.28) | 10 | 1.03 (0.52–2.04) | 69 | 0.92 (0.67–1.28) | 50 | 0.99 (0.69–1.41) | 123 | ref | 181 | 1.03 (0.80–1.33) | 54 | 0.91 (0.64–1.28) | 66 | 1.32 (0.95–1.84) |
| ICH | 378 | 86 | 1.56* (1.13–2.16) | 18 | 2.53* (1.50–4.26) | 68 | 1.40 (0.99–1.98) | 37 | 1.05 (0.68–1.61) | 82 | ref | 102 | 0.97 (0.71–1.33) | 32 | 0.85 (0.55–1.33) | 39 | 1.45 (0.96–2.17) |
LDL-C, low-density lipoprotein cholesterol; CVD, cardiovascular disease; CHD, coronary heart disease; ICH, intracerebral hemorrhage; HR, hazard ratio; CI, confidence interval. To convert mg/dL to mmol/L, multiply by 0.0259.
*
Indicates a significant (p < 0.05) death rate compared to LDL-C levels between 110 and 129 mg/dL. Hazard ratio adjusted for age, gender, body mass index, smoking status, alcohol consumption, physical activity, systolic blood pressure, fasting glucose level, and anemia.