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. 2022 Jan 17;9:790847. doi: 10.3389/fcell.2021.790847

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Copyright © 2022 Della Gaspera, Weill and Chanoine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main functions of BMP, FGF, Wnt, and Shh signalings during somite compartmentalization in anamniotes (A) and amniotes (B). Somite compartmentalization depends on signals expressed by surrounding tissues. Shh is expressed by notochord (NC) and floor plate, Wnt by surface ectoderm (SE) and dorsal neural tube (NT) and BMP4 by lateral plate mesoderm (LPM). Most of the functions fulfilled by the signaling molecules seem to be conserved between anamniotes (A) and amniotes (B). However, it seems that Fgf and to a lesser extent Wnt may play an early role in the formation of primitive myotome only in anamniotes (A). Arrows, promoting effect; T-shaped line, inhibitory effect.