Table 3.
Multivariate Analyses for Clinical Predictors of Death Among Patients With Cryptococcal Meningitis
| Variables | Hazard Ratio | Standard Error | T Value | P Value | 95% CI of the Hazard Ratio |
|---|---|---|---|---|---|
| ART status | |||||
| Not on ART (n = 19) | 1.000 | … | … | … | |
| On ART (n = 156) | 0.197 | 0.167 | –1.92 | .055 | .037–1.035 |
| Stopped completely (n = 14) | 0.107 | 0.108 | –2.21 | .027a | .015–.777 |
| Restarted (n = 20) | 0.000 | … | … | … | |
| Fever | |||||
| No (n = 27) | 1.000 | … | … | … | |
| Yes (n = 144) | 3.024 | 2.020 | 1.66 | .098 | .817–11.196 |
| Altered mentation | |||||
| No (n = 91) | 1.000 | … | … | … | |
| Yes (n = 65) | 6.627 | 3.420 | 3.67 | .0001a | 2.411–18.219 |
| Vomiting | |||||
| No (n = 73) | 1.000 | … | … | … | |
| Yes (n = 82) | 2.176 | 0.984 | 1.72 | .085 | .897–5.277 |
| Seizure | |||||
| No (n = 116) | 1.000 | … | … | … | |
| Yes (n = 16) | 5.232 | 3.833 | 2.26 | .024a | 1.245–21.991 |
| Abnormal X-ray | |||||
| No (n = 93) | 1.000 | … | … | … | |
| Yes (n = 31) | 1.452 | 0.659 | 0.82 | .411 | .597–3.533 |
| Oxygen saturation | |||||
| >90% (n = 89) | 1.000 | … | … | … | |
| ≤90% (n = 4) | 1.016 | 0.022 | –3.07 | .002a | .001–.227 |
| Mean dependent variable | 18.333 | ||||
| Pseudo r2 | 0.215 | ||||
| χ2 | 39.938 | ||||
| AIC | 161.903 | ||||
| SD dependent variable | 13.726 | ||||
| No. of observations | 54.000 | ||||
| Probability > χ2 | 0.000 | ||||
| BIC | 177.814 | ||||
Cox proportional hazard regression analysis; results adjusted for confounders.
Abbreviations: AIC, Akaike information criterion; ART, antiretroviral therapy; BIC, Bayesian information criterion; SD, standard deviation.
Level of significance: P < .05.