Figure 5. Chemical shift changes in DSPE-PEG2000 during DOX titration into the DSPE-PEG2000.
(A) Chemical shifts movement of 1H(P) and 6H(P) of DSPE-PEG2000 versus the several initial titration points of DOX. (B) Global curve fitting of chemical shift perturbation of four protons of DSPE-PEG2000 versus the titration of DOX. The 6H(P) peak started to merge with 4*H(P), and thus no more data was available after molar ratio of DOX:DSPE-PEG2000 was larger than 3.56.