Table 1.
KCC2 Protein partners identified by MS
| Gene name | UniProt ID | Protein name | TM | Ratio KCC2/sham MS-MS count |
Mean ratio KCC2/sham. MS-MS count | ||
|---|---|---|---|---|---|---|---|
| N1 | N2 | N3 | |||||
| * Slc12a5 | Q63633 | Solute Carrier Family 12 Member 5 | x | 214.0 | 11.7 | 77.4 | 101.0 |
| * Canx | P35565 | Calnexin | x | 4.4 | 1.9 | 27.0 | 11.1 |
| Npepps | F1M9V7 | Aminopeptidase Puromycin Sensitive | x | 3.0 | 1.7 | 28.0 | 10.9 |
| Dpysl5 | Q9JHU0 | Dihydropyrimidinase-Like 5 | 2.0 | 1.5 | 21.0 | 8.2 | |
| * Jagn1 | Q4KM64 | Jagunal Homolog 1 | x | 5.0 | 17.0 | 2.0 | 8.0 |
| Tkt | G3V826 | Transketolase | 1.7 | 2.1 | 20.0 | 7.9 | |
| Opa1 | Q2TA68 | Opa1, Mitochondrial Dynamin Like Gtpase | x | 2.5 | 1.0 | 20.0 | 7.8 |
| * Sfpq | A0A0G2K8K0 | Splicing Factor Proline and Glutamine Rich | 4.0 | 1.1 | 18.0 | 7.7 | |
| Immt | A0A0G2JVH4 | Inner Membrane Mitochondrial Protein | x | 2.0 | 1.0 | 20.0 | 7.7 |
| Slc3a2 | A0A0H2UHQ0 | Solute Carrier Family 3 Member 2 | 2.7 | 1.3 | 19.0 | 7.6 | |
| * Cpsf6 | D3ZPL1 | Cleavage and Polyadenylation Specific factor 6 | 4.0 | 1.6 | 15.0 | 6.9 | |
| Hsp90b1 | Q66HD0 | Heat Shock Protein 90 β Family Member 1 | 5.0 | 1.1 | 14.0 | 6.7 | |
| Eef2 | P05197 | Eukaryotic Translation Elongation factor 2 | 3.5 | 1.6 | 14.0 | 6.4 | |
| Qars | Q66H61 | Glutaminyl-Trna Synthetase | 2.0 | 1.0 | 16.0 | 6.3 | |
| Ptprs | Q64605 | Protein Tyrosine Phosphatase, Receptor Type, S | x | 1.6 | 3.3 | 14.0 | 6.3 |
| Jup | Q6P0K8 | Junction Plakoglobin | 3.0 | 0.7 | 15.0 | 6.2 | |
| Slc25a12 | F1LX07 | Solute Carrier Family 25 Member 12 | x | 2.5 | 0.8 | 15.0 | 6.1 |
| Adam22 | F1M542 | Adam Metallopeptidase Domain 22 | 3.0 | 1.0 | 14.0 | 6.0 | |
| Uggt1 | Q9JLA3 | Udp-Glucose Glycoprotein Glucosyltransferase 1 | 3.0 | 1.0 | 13.0 | 5.7 | |
| Hspa4l | F7F2F3 | Heat Shock Protein 4-Like | 3.5 | 1.4 | 12.0 | 5.6 | |
| Acsl6 | P33124 | Acyl-Coa Synthetase Long-Chain Family Member 6 | x | 3.0 | 1.3 | 12.0 | 5.4 |
| Gucy1b3 | P20595 | Guanylate Cyclase 1 Soluble Subunit β 3 | 4.0 | 1.2 | 11.0 | 5.4 | |
| Gys1 | A2RRU1 | Glycogen Synthase 1 | 4.0 | 0.9 | 11.0 | 5.3 | |
| Dhx36 | D4A2Z8 | Deah-Box Helicase 36 | 6.0 | 1.4 | 8.0 | 5.1 | |
| * Slc8a2 | P48768 | Solute Carrier Family 8 Member A2 | x | 7.0 | 1.3 | 7.0 | 5.1 |
| Slc27a1 | Q6GMM8 | Solute Carrier Family 27 Member 1 | 3.0 | 1.3 | 11.0 | 5.1 | |
| Letm1 | Q5XIN6 | Leucine Zipper and Ef-Hand Containing Transmembrane Protein 1 | x | 1.0 | 2.1 | 12.0 | 5.0 |
| Aldh1l1 | P28037 | Aldehyde Dehydrogenase 1 Family, Member L1 | 5.0 | 1.1 | 9.0 | 5.0 | |
| Mars | D3Z941 | Methionyl-Trna Synthetase | 2.0 | 0.9 | 12.0 | 5.0 | |
| * Sec23a | A0A0G2JZM2 | Sec23 Homolog A, Coat Complex II Component | 2.0 | 0.9 | 12.0 | 5.0 | |
| Rph3a | F1LPB9 | Rabphilin 3A | 3.7 | 0.9 | 10.0 | 4.9 | |
| Sirpa | P97710 | Signal-Regulatory Protein α | x | 2.0 | 3.8 | 8.0 | 4.6 |
| Trim28 | O08629 | Tripartite Motif-Containing 28 | 1.0 | 2.5 | 10.0 | 4.5 | |
| Kpnb1 | F2Z3Q8 | Karyopherin Subunit β 1 | 1.3 | 2.0 | 10.0 | 4.4 | |
| Ago1 | D4AC38 | Argonaute 1, Risc Catalytic Component | 3.3 | 0.8 | 9.0 | 4.4 | |
| Elob | P62870 | Transcription Elongation factor B Subunit 2 | 10.0 | 2.3 | 0.7 | 4.3 | |
| Slitrk5 | M0R9U3 | Slit and Ntrk-Like Family, Member 5 | 3.0 | 0.9 | 9.0 | 4.3 | |
| Exoc3 | Q62825 | Exocyst Complex Component 3 | 3.0 | 0.8 | 9.0 | 4.3 | |
| Syn3 | O70441 | Synapsin III | 2.0 | 0.8 | 10.0 | 4.3 | |
| Sf3b1 | G3V7T6 | Splicing factor 3B, Subunit 1 | 4.0 | 0.7 | 8.0 | 4.2 | |
| Scyl1 | Q5M9F8 | Scy1 Like Pseudokinase 1 | 2.7 | 0.9 | 9.0 | 4.2 | |
| Srp72 | D4A7R0 | Signal Recognition Particle 72 | 2.0 | 1.5 | 9.0 | 4.2 | |
| * Gls | P13264 | Glutaminase | 4.0 | 1.4 | 7.0 | 4.1 | |
| Pspc1 | Q4KLH4 | Paraspeckle Component 1 | 1.0 | 2.0 | 9.0 | 4.0 | |
| Mta2 | B2GV01 | Metastasis Associated 1 Family, Member 2 | 4.0 | 0.9 | 7.0 | 4.0 | |
| Dlg4 | P31016 | Discs Large Maguk Scaffold Protein 4 | 2.0 | 0.9 | 9.0 | 4.0 | |
| Rpn2 | P25235 | Ribophorin II | x | 4.0 | 1.4 | 6.0 | 3.8 |
| N/A | A0A0G2JY03 | Uncharacterized protein | 2.0 | 1.2 | 8.0 | 3.7 | |
| FbxO21 | F1M5Q6 | F-Box Protein 21 | 4.5 | 0.7 | 6.0 | 3.7 | |
| Trim32 | Q66H79 | Tripartite Motif-Containing 32 | 2.0 | 1.2 | 8.0 | 3.7 | |
| Cadm2 | Q1WIM2 | Cell Adhesion Molecule 2 | x | 4.0 | 3.0 | 4.0 | 3.7 |
| Copg1 | Q4AEF8 | Coatomer Protein Complex, Subunit γ 1 | 2.0 | 1.0 | 8.0 | 3.7 | |
| Pygm | G3V8V3 | Phosphorylase, Glycogen, Muscle | 2.0 | 0.9 | 8.0 | 3.6 | |
| Hnrnpl | F1LQ48 | Heterogeneous Nuclear Ribonucleoprotein L | 4.0 | 0.7 | 6.0 | 3.6 | |
| Rap1gap | F1LV89 | Rap1 Gtpase-Activating Protein | 2.7 | 0.8 | 7.0 | 3.5 | |
| Cttn | Q66HL2 | Cortactin | 3.5 | 0.9 | 6.0 | 3.5 | |
| Plaa | P54319 | Phospholipase A2, Activating Protein | 6.0 | 1.4 | 3.0 | 3.5 | |
| Vps33a | Q63615 | Vps33A Corvet/Hops Core Subunit | 2.3 | 0.9 | 7.0 | 3.4 | |
| Khsrp | Q99PF5 | Kh-type Splicing Regulatory Protein | 2.0 | 1.1 | 7.0 | 3.4 | |
| Upf1 | A0A0U1RS25 | Upf1, Rna Helicase and Atpase | 2.0 | 1.1 | 7.0 | 3.4 | |
| Ndufs2 | Q641Y2 | Nadh Dehydrogenase Ubiquinone Fe-S Protein 2 | 6.0 | 2.0 | 2.0 | 3.3 | |
| Hyou1 | Q63617 | Hypoxia Up-Regulated 1 | 1.0 | 2.0 | 7.0 | 3.3 | |
| Iars | A0A0G2JVL8 | Isoleucyl-Trna Synthetase | 2.0 | 1.0 | 7.0 | 3.3 | |
| Mut | D3ZKG1 | Methylmalonyl Coa Mutase | 2.0 | 1.0 | 7.0 | 3.3 | |
| Faah | P97612 | Fatty Acid Amide Hydrolase | x | 1.0 | 3.0 | 6.0 | 3.3 |
| * Adgrl2 | O88923 | Adhesion G Protein-Coupled Receptor L2 | x | 1.0 | 3.0 | 6.0 | 3.3 |
| Eif2ak3 | Q9Z1Z1 | Eukaryotic Translation Initiation factor 2 Alpha Kinase 3 | x | 4.0 | 0.9 | 5.0 | 3.3 |
| Rangap1 | F1MAA5 | Ran Gtpase Activating Protein 1 | 2.0 | 0.7 | 7.0 | 3.2 | |
| * Prrt2 | D3ZFB6 | Proline-Rich Transmembrane Protein 2 | x | 2.0 | 2.6 | 5.0 | 3.2 |
| Aak1 | P0C1X8 | Ap2 Associated Kinase 1 | 2.0 | 1.8 | 5.8 | 3.2 | |
| Palm | Q920Q0 | Paralemmin | 3.0 | 1.1 | 5.5 | 3.2 | |
| Apoe | P02650 | Apolipoprotein E | 3.0 | 6.0 | 0.3 | 3.1 | |
| Ivns1abp | A0A0G2K427 | Influenza Virus Ns1A Binding Protein | 2.4 | 0.8 | 6.0 | 3.1 | |
| Slain2 | G3V6A2 | Slain Motif Family, Member 2 | 2.0 | 3.0 | 4.0 | 3.0 | |
| Dnm3 | Q08877 | Dynamin 3 | 1.0 | 2.0 | 6.0 | 3.0 | |
| Sdha | Q920L2 | Succinate Dehydrogenase Complex Flavoprotein Subunit A | 3.0 | 0.9 | 5.0 | 3.0 | |
| Slc6a11 | P31647 | Solute Carrier Family 6 Member 11 | x | 1.0 | 3.7 | 4.0 | 2.9 |
| Madd | O08873 | Map-Kinase Activating Death Domain | 1.0 | 2.6 | 5.0 | 2.9 | |
| Ptpn11 | P41499 | Protein Tyrosine Phosphatase, Non-Receptor type 11 | 4.0 | 1.6 | 3.0 | 2.9 | |
| Camk2b | P08413 | Calcium/Calmodulin-Dependent Protein Kinase II Beta | 5.3 | 1.2 | 2.0 | 2.8 | |
| * Actn4 | Q9QXQ0 | Actinin α 4 | 2.5 | 1.0 | 5.0 | 2.8 | |
| Mccc1 | Q5I0C3 | Methylcrotonoyl-Coa Carboxylase 1 | 2.0 | 0.4 | 6.0 | 2.8 | |
| Gps1 | P97834 | G Protein Pathway Suppressor 1 | 4.0 | 1.3 | 3.0 | 2.8 | |
| Vps45 | O08700 | Vacuolar Protein Sorting 45 | 2.0 | 1.3 | 5.0 | 2.8 | |
| Dlg1 | Q62696 | Discs Large Maguk Scaffold Protein 1 | 3.0 | 1.3 | 4.0 | 2.8 | |
| Sort1 | O54861 | Sortilin 1 | x | 3.0 | 1.3 | 4.0 | 2.8 |
| Ubxn6 | A0A0G2K012 | Ubx Domain Protein 6 | 4.0 | 1.2 | 3.0 | 2.7 | |
| Edf1 | P69736 | Endothelial Differentiation-Related factor 1 | 4.0 | 2.8 | 1.4 | 2.7 | |
| * Ndufs1 | Q66HF1 | Nadh Dehydrogenase Ubiquinone Fe-S Protein 1 | 2.0 | 1.1 | 5.0 | 2.7 | |
| Soga3 | D4A0A1 | Soga Family Member 3 | 2.3 | 0.8 | 5.0 | 2.7 | |
| Cops3 | Q68FW9 | Cop9 Signalosome Subunit 3 | 5.0 | 2.3 | 0.8 | 2.7 | |
| Cds2 | Q91XU8 | Cdp-Diacylglycerol Synthase 2 | 3.0 | 2.0 | 3.0 | 2.7 | |
| Syt2 | P29101 | Synaptotagmin 2 | x | 2.0 | 2.0 | 4.0 | 2.7 |
| Hint1 | P62959 | Histidine Triad Nucleotide Binding Protein 1 | 2.0 | 5.0 | 1.0 | 2.7 | |
| Psmb6 | P28073 | Proteasome Subunit β 6 | 1.0 | 3.0 | 4.0 | 2.7 | |
| * Dhx9 | D4A9D6 | Dexh-Box Helicase 9 | 5.0 | 1.0 | 2.0 | 2.7 | |
| Lmna | G3V8L3 | Lamin A/C | 2.0 | 1.0 | 5.0 | 2.7 | |
| Rpl12 | P23358 | Ribosomal Protein L12 | 4.0 | 1.0 | 3.0 | 2.7 | |
| Pank4 | Q923S8 | Pantothenate Kinase 4 | 2.0 | 1.0 | 5.0 | 2.7 | |
| Cul1 | B1WBY1 | Cullin 1 | 3.0 | 1.0 | 4.0 | 2.7 | |
| Psma3 | P18422 | Proteasome Subunit Alpha 3 | 3.0 | 3.5 | 1.5 | 2.7 | |
| Epb41l2 | D3ZAY7 | Erythrocyte Membrane Protein Band 4.1-Like 2 | 2.0 | 1.7 | 4.3 | 2.7 | |
| Mpp2 | D3ZAA9 | Membrane Palmitoylated Protein 2 | 2.3 | 1.5 | 4.2 | 2.7 | |
| Napb | F8WFM2 | Nsf Attachment Protein β | 5.0 | 2.3 | 0.4 | 2.6 | |
| Cntn1 | Q63198 | Contactin 1 | 1.5 | 2.7 | 3.5 | 2.6 | |
| Ehd1 | Q641Z6 | Eh-Domain Containing 1 | 2.0 | 2.7 | 3.0 | 2.6 | |
| Add1 | Q63028 | Adducin 1 | 2.0 | 1.0 | 4.6 | 2.5 | |
| Usp15 | A0A0A0MY07 | Ubiquitin Specific Peptidase 15 | 2.3 | 0.8 | 4.5 | 2.5 | |
| Synj1 | Q62910 | Synaptojanin 1 | 3.0 | 1.7 | 2.8 | 2.5 | |
| Rbmx | Q4V898 | Rna Binding Motif Protein, X-Linked | 5.0 | 2.0 | 0.5 | 2.5 | |
| Slc24a2 | O54701-2 | Sodium/potassium/calcium exchanger 2 | x | 1.0 | 4.5 | 2.0 | 2.5 |
| Hepacam | D3ZEI4 | Hepatic and Glial Cell Adhesion Molecule | 2.0 | 1.5 | 4.0 | 2.5 | |
| Brsk2 | D3ZML2-2 | Serine/threonine-protein kinase BRSK2 | 2.0 | 1.4 | 4.0 | 2.5 | |
| Epb41l3 | G3V874 | Erythrocyte Membrane Protein Band 4.1-Like 3 | 2.0 | 1.3 | 4.0 | 2.4 | |
| Klhl22 | D3ZZC3 | Kelch-Like Family Member 22 | 2.0 | 1.3 | 4.0 | 2.4 | |
| Map3k7 | P0C8E4 | Mitogen Activated Protein Kinase Kinase Kinase 7 | 2.0 | 1.3 | 4.0 | 2.4 | |
| Wdr48 | D3Z8C7 | Wd Repeat Domain 48 | 3.0 | 1.3 | 3.0 | 2.4 | |
| Acadvl | P45953 | Acyl-Coa Dehydrogenase, Very Long Chain | 2.0 | 1.3 | 4.0 | 2.4 | |
| Gpd1 | O35077 | Glycerol-3-Phosphate Dehydrogenase 1 | 3.0 | 3.3 | 0.9 | 2.4 | |
| Krt77 | Q6IG01 | Keratin 77 | 5.0 | 2.0 | 0.2 | 2.4 | |
| Gphn | Q03555 | Gephyrin | 2.0 | 1.2 | 4.0 | 2.4 | |
| Ppm1e | Q80Z30 | Protein Phosphatase, Mg2+/Mn2+ Dependent, 1E | 2.0 | 1.1 | 4.0 | 2.4 | |
| Cadm3 | Q1WIM3 | Cell Adhesion Molecule 3 | x | 2.0 | 3.0 | 2.0 | 2.3 |
| Acyp2 | P35745 | Acylphosphatase 2 | 2.0 | 3.0 | 2.0 | 2.3 | |
| Aplp1 | F1LRS5 | Amyloid Beta Precursor Like Protein 1 | x | 2.0 | 3.0 | 2.0 | 2.3 |
| Poldip2 | E9PT51 | Dna Polymerase δ Interacting Protein 2 | 2.0 | 3.0 | 2.0 | 2.3 | |
| Brcc3 | B2RYM5 | Brca1/Brca2-Containing Complex, Subunit 3 | 3.0 | 2.0 | 2.0 | 2.3 | |
| Gria2 | P19491 | Glutamate Ionotropic Receptor Ampa type Subunit 2 | x | 1.0 | 2.0 | 4.0 | 2.3 |
| Ggt7 | Q99MZ4 | γ-Glutamyltransferase 7 | x | 1.0 | 2.0 | 4.0 | 2.3 |
| Cpne7 | H1UBN0 | Copine 7 | 1.0 | 3.0 | 3.0 | 2.3 | |
| Mtmr9 | Q5XIN4 | Myotubularin Related Protein 9 | 3.0 | 1.0 | 3.0 | 2.3 | |
| Gsta3 | P04904 | Glutathione S-Transferase β 1 | 1.0 | 2.0 | 4.0 | 2.3 | |
| Lrpprc | Q5SGE0 | Leucine-Rich Pentatricopeptide Repeat Containing | 4.0 | 0.7 | 2.3 | 2.3 | |
| Phgdh | O08651 | Phosphoglycerate Dehydrogenase | 2.0 | 3.7 | 1.2 | 2.3 | |
| Plec | Q6S399 | Plectin | 4.0 | 0.8 | 2.0 | 2.3 | |
| Eif5 | Q07205 | Eukaryotic Translation Initiation factor 5 | 4.0 | 2.0 | 0.8 | 2.3 | |
| Gap43 | P07936 | Growth Associated Protein 43 | 3.2 | 1.3 | 2.3 | 2.3 | |
| Pde1a | A0A0G2JZX9 | Phosphodiesterase 1A | 3.0 | 2.5 | 1.3 | 2.3 | |
| Sel1l | Q80Z70 | Sel1L Erad E3 Ligase Adaptor Subunit | x | 2.0 | 1.7 | 3.0 | 2.2 |
| Rab3d | Q63942 | Rab3D, Member Ras Oncogene Family | 3.0 | 2.0 | 1.7 | 2.2 | |
| Ndrg2 | Q8VBU2-2 | Protein NDRG2 | 4.0 | 2.3 | 0.3 | 2.2 | |
| Prag1 | D3ZMK9 | Pragma Of Rnd2 | 4.0 | 0.5 | 2.0 | 2.2 | |
| Kcnj10 | P49655 | Potassium Voltage-Gated Channel Subfamily J Member 10 | x | 1.5 | 2.0 | 3.0 | 2.2 |
| Ngef | Q5BKC9 | Neuronal Guanine Nucleotide Exchange Factor | 2.5 | 1.0 | 3.0 | 2.2 | |
| Rps5 | P24050 | Ribosomal Protein S5 | 3.0 | 3.0 | 0.4 | 2.1 | |
| Wasf3 | M0R7F3 | Was Protein Family, Member 3 | 3.0 | 0.4 | 3.0 | 2.1 | |
| Tnrc6b | A0A0G2K6R0 | Trinucleotide Repeat Containing 6B | 4.0 | 0.3 | 2.0 | 2.1 | |
| Dnajb12 | Q5FVC4 | Dnaj Heat Shock Protein Family Hsp40 Member B12 | x | 3.0 | 2.0 | 1.3 | 2.1 |
| Dnajc5 | P60905 | Dnaj Heat Shock Protein Family (Hsp40) Member C5 | 3.0 | 2.7 | 0.6 | 2.1 | |
| Gdap1 | D4A5X7 | Ganglioside-Induced Differentiation-Associated-Protein 1 | 2.0 | 3.5 | 0.7 | 2.1 | |
| Aldh2 | P11884 | Aldehyde Dehydrogenase 2 Family Mitochondrial | 3.0 | 2.5 | 0.7 | 2.1 | |
| Copg2 | D4ABY2 | Coatomer Protein Complex, Subunit γ 2 | 2.0 | 1.2 | 3.0 | 2.1 | |
| Phactr1 | P62024 | Phosphatase and Actin Regulator 1 | 2.5 | 1.0 | 2.7 | 2.1 | |
| Nipsnap2 | Q5RK08 | Glioblastoma Amplified Sequence | 3.0 | 1.1 | 2.0 | 2.0 | |
| Lsm4 | D4A2C6 | Lsm4 Homolog, U6 Small Nuclear Rna and Mrna Degradation Associated | 2.0 | 2.0 | 2.0 | 2.0 | |
| Dnajb14 | A0A0G2JTM9 | Dnaj Heat Shock Protein Family Hsp40 Member B14 | x | 2.0 | 2.0 | 2.0 | 2.0 |
| Lin7b | Q9Z252 | Lin-7 Homolog B, Crumbs Cell Polarity Complex Component | 1.0 | 3.0 | 2.0 | 2.0 | |
| Ndrg3 | Q6AYR2 | Ndrg Family Member 3 | 1.0 | 3.0 | 2.0 | 2.0 | |
| Hspa2 | P14659 | Heat Shock Protein Family A Member 2 | 2.0 | 3.0 | 1.0 | 2.0 | |
| Zwint | Q8VIL3 | Zw10 Interacting Kinetochore Protein | 3.0 | 2.0 | 1.0 | 2.0 | |
| Synm | A0A096MK54 | Synemin | 2.0 | 3.0 | 1.0 | 2.0 | |
| Gad2 | Q05683 | Glutamate Decarboxylase 2 | 1.0 | 2.0 | 3.0 | 2.0 | |
| * Fasn | P12785 | Fatty Acid Synthase | 2.0 | 0.8 | 3.0 | 2.0 | |
| Vars | Q04462 | Valyl-Trna Synthetase | 2.0 | 1.6 | 2.3 | 1.9 | |
| Aspscr1 | A0A0G2JWF4 | Aspscr1, Ubx Domain Containing Tether For Slc2A4 | 2.0 | 0.8 | 3.0 | 1.9 | |
| * Lgi3 | D3ZN61 | Leucine-Rich Repeat Lgi Family, Member 3 | 2.0 | 3.0 | 0.8 | 1.9 | |
| Rtn1 | Q64548 | Reticulon 1 | x | 2.1 | 1.2 | 2.4 | 1.9 |
| Pitpna | P16446 | Phosphatidylinositol Transfer Protein, α | 2.0 | 3.3 | 0.4 | 1.9 | |
| Dync1i2 | Q62871 | Dynein cytoplasmic 1 intermediate chain 2 | 2.0 | 0.7 | 3.0 | 1.9 | |
| Magi2 | A0A0G2JXR9 | Membrane Associated Guanylate Kinase, Ww AND Pdz Domain Containing 2 | 2.5 | 0.2 | 3.0 | 1.9 | |
| Ubxn2b | P0C627 | Ubx Domain Protein 2B | 2.0 | 1.7 | 2.0 | 1.9 | |
| Vps16 | Q642A9 | Vps16 Corvet/Hops Core Subunit | 2.0 | 0.6 | 3.0 | 1.9 | |
| Vsnl1 | P62762 | Visinin-Like 1 | 3.0 | 2.1 | 0.4 | 1.8 | |
| Adgrl1 | O88917 | Adhesion G Protein-Coupled Receptor L1 | x | 2.0 | 0.9 | 2.6 | 1.8 |
| Gatad2b | Q4V8E1 | Gata Zinc Finger Domain Containing 2B | 2.0 | 0.5 | 3.0 | 1.8 | |
| Fbxl16 | Q5MJ12 | F-Box and Leucine-Rich Repeat Protein 16 | 3.0 | 2.0 | 0.5 | 1.8 | |
| * Ddx17 | E9PT29 | Dead-Box Helicase 17 | 2.0 | 0.5 | 3.0 | 1.8 | |
| Mgp | P08494 | Matrix Gla Protein | 2.0 | 1.0 | 2.5 | 1.8 | |
| Abi1 | Q9QZM5 | Abl-Interactor 1 | 2.0 | 1.5 | 2.0 | 1.8 | |
| * Cct5 | Q68FQ0 | Chaperonin Containing Tcp1 Subunit 5 | 2.2 | 1.1 | 2.1 | 1.8 | |
| Elavl1 | B5DF91 | Elav Like Rna Binding Protein 1 | 3.0 | 2.0 | 0.4 | 1.8 | |
| Sec22b | Q4KM74 | Sec22 Homolog B, Vesicle Trafficking Protein | x | 2.0 | 1.3 | 2.0 | 1.8 |
| Rap1gds1 | A0A0G2K1D2 | Rap1 Gtpase-Gdp Dissociation Stimulator 1 | 2.3 | 2.2 | 0.8 | 1.8 | |
| Serpinh1 | Q5RJR9 | Serpin Family H Member 1 | 2.0 | 2.7 | 0.5 | 1.7 | |
| Tmx1 | Q52KJ9 | Thioredoxin-Related Transmembrane Protein 1 | 1.0 | 2.0 | 2.0 | 1.7 | |
| LOC367746 | F1LPW6 | Similar To Spindlin-Like Protein 2, Spin-2 | 2.0 | 1.0 | 2.0 | 1.7 | |
| Fn3k | D3ZZU8 | Fructosamine 3 Kinase | 2.0 | 2.0 | 1.0 | 1.7 | |
| Purb | Q68A21 | Purine Rich Element Binding Protein B | 2.0 | 1.0 | 2.0 | 1.7 | |
| Gstm5 | Q9Z1B2 | Glutathione S-Transferase, Mu 5 | 2.0 | 0.8 | 2.0 | 1.6 | |
| Napg | A0A0G2K350 | Nsf Attachment Protein γ | 2.0 | 2.2 | 0.5 | 1.6 | |
| Rab10 | Q5RKJ9 | Rab10, member Ras oncogene family | 2.0 | 2.0 | 0.6 | 1.5 | |
| Naca | B2RYX0 | Nascent Polypeptide-Associated Complex α Subunit | 2.0 | 2.0 | 0.6 | 1.5 | |
| * Ina | G3V8Q2 | Internexin Neuronal Intermediate Filament Protein, α | 2.0 | 0.5 | 2.0 | 1.5 | |
| Cpsf7 | Q5XI29 | Cleavage and Polyadenylation Specific Factor 7 | 2.0 | 0.5 | 2.0 | 1.5 | |
| Habp4 | A1L1K8 | Hyaluronan Binding Protein 4 | 2.0 | 0.3 | 2.2 | 1.5 | |
| Vps26b | B1WBS4 | Vps26 Retromer Complex Component B | 2.0 | 2.0 | 0.4 | 1.5 | |
| Hapln4 | D3Z9H2 | Hyaluronan and Proteoglycan Link Protein 4 | 2.0 | 2.0 | 0.3 | 1.4 | |
| Tst | P24329 | Thiosulfate Sulfurtransferase | 2.0 | 2.0 | 0.3 | 1.4 | |
| Acsm3 | Q6SKG1 | Acyl-Coa Synthetase Medium-Chain Family Member 3 | 0.0 | 12.0 | 5.0 | 5.7 | |
| Acly | P16638 | Atp Citrate Lyase | 0.0 | 2.5 | 10.0 | 4.2 | |
| Ezr | P31977 | Ezrin | 0.0 | 5.0 | 7.0 | 4.0 | |
| Acad9 | B1WC61 | Acyl-Coa Dehydrogenase Family, Member 9 | 0.0 | 2.0 | 9.0 | 3.7 | |
| Fip1l1 | Q5U317 | Factor Interacting With Papola and Cpsf1 | 0.0 | 3.0 | 8.0 | 3.7 | |
| Ehd4 | Q8R3Z7 | Eh-Domain Containing 4 | 0.0 | 6.0 | 4.0 | 3.3 | |
| Dpp10 | Q6Q629 | Dipeptidylpeptidase 10 | x | 0.0 | 2.0 | 8.0 | 3.3 |
| Pdia3 | P11598 | Protein Disulfide Isomerase Family A, Member 3 | 0.0 | 2.8 | 7.0 | 3.3 | |
| Uba1 | Q5U300 | Ubiquitin-Like Modifier Activating Enzyme 1 | 0.0 | 2.8 | 7.0 | 3.3 | |
| Tf | A0A0G2QC06 | Transferrin | 0.0 | 2.5 | 7.0 | 3.2 | |
| Plxnb1 | D3ZDX5 | Plexin B1 | x | 0.0 | 3.0 | 6.0 | 3.0 |
| Nomo1 | D3ZSA9 | Nodal Modulator 1 | 0.0 | 5.0 | 4.0 | 3.0 | |
| Stxbp5 | Q9WU70 | Syntaxin Binding Protein 5 | 0.0 | 2.0 | 7.0 | 3.0 | |
| Ogt | P56558 | O-Linked N-Acetylglucosamine Glcnac Transferase | 0.0 | 2.3 | 6.0 | 2.8 | |
| Cspg5 | Q9ERQ6-2 | Chondroitin Sulfate Proteoglycan 5 | x | 0.0 | 2.3 | 6.0 | 2.8 |
| Efr3b | F1LTW9 | Efr3 Homolog B | 0.0 | 5.0 | 3.0 | 2.7 | |
| Kif21a | D4A1V5 | Kinesin Family Member 21A | 0.0 | 2.0 | 6.0 | 2.7 | |
| Tpp2 | Q64560 | Tripeptidyl Peptidase 2 | 0.0 | 3.7 | 4.0 | 2.6 | |
| Alcam | O35112 | Activated Leukocyte Cell Adhesion Molecule | x | 0.0 | 2.3 | 5.0 | 2.4 |
| Lingo1 | G3V881 | Leucine Rich Repeat and Ig Domain Containing 1 | 0.0 | 4.0 | 3.0 | 2.3 | |
| ATP8 | P11608 | Atpase Subunit 8 | x | 0.0 | 3.0 | 4.0 | 2.3 |
| Itfg1 | Q5U355 | Integrin Alpha Fg-Gap Repeat Containing 1 | x | 0.0 | 2.0 | 5.0 | 2.3 |
| Pik3r4 | P0C0R5 | Phosphoinositide-3-Kinase, Regulatory Subunit 4 | 0.0 | 3.0 | 4.0 | 2.3 | |
| Scamp5 | Q9JKE3 | Secretory Carrier Membrane Protein 5 | x | 0.0 | 3.0 | 4.0 | 2.3 |
| Mogs | O88941 | Glucosidase 1 | x | 0.0 | 2.0 | 5.0 | 2.3 |
| Cd200 | A0A5D0 | Cd200 Molecule | 0.0 | 5.0 | 2.0 | 2.3 | |
| Gpm6b | Q9JJK1 | Glycoprotein M6B | x | 0.0 | 4.0 | 2.5 | 2.2 |
| Pithd1 | D4ABS5 | Pith Domain Containing 1 | 0.0 | 2.5 | 4.0 | 2.2 | |
| S100b | P04631 | S100 Calcium Binding Protein B | 0.0 | 4.0 | 2.5 | 2.2 | |
| Pak1 | P35465 | P21 Activated Kinase 1 | 0.0 | 3.0 | 3.0 | 2.0 | |
| Abcb7 | Q704E8 | Atp Binding Cassette Subfamily B Member 7 | x | 0.0 | 4.0 | 2.0 | 2.0 |
| * Hk1 | M0RAQ6 | Hexokinase 1 | 0.0 | 4.0 | 2.0 | 2.0 | |
| Arl3 | P37996 | Adp Ribosylation factor Like Gtpase 3 | 0.0 | 4.0 | 2.0 | 2.0 | |
| Pfkl | P30835 | Phosphofructokinase, Liver Type | 0.0 | 2.0 | 4.0 | 2.0 | |
| Pex5l | Q925N3 | Peroxisomal Biogenesis factor 5-Like | 0.0 | 2.0 | 4.0 | 2.0 | |
| Llgl1 | Q8K4K5 | Llgl1, Scribble Cell Polarity Complex Component | 0.0 | 4.0 | 2.0 | 2.0 | |
| RGD1307235 | D3ZJ01 | Similar to Riken Cdna 2310035C23 | 0.0 | 2.5 | 3.5 | 2.0 | |
| Ppp2r5d | F1MAA3 | Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit δ Isoform-Like | 0.0 | 2.0 | 4.0 | 2.0 | |
| Hgs | Q9JJ50 | Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate | 0.0 | 4.0 | 2.0 | 2.0 | |
| Tgm3 | D4A5U3 | Transglutaminase 3 | 4.0 | 2.0 | 0.0 | 2.0 | |
| Cadps | Q62717 | Calcium Dependent Secretion Activator | 0.0 | 2.0 | 3.3 | 1.8 | |
| Cd9 | P40241 | Cd9 Molecule | x | 0.0 | 3.0 | 2.0 | 1.7 |
| Map2k6 | Q925D6 | Mitogen-Activated Protein Kinase Kinase 6 | 0.0 | 3.0 | 2.0 | 1.7 | |
| Vps33b | Q63616 | Vps33B, Late Endosome and Lysosome Associated | 0.0 | 2.0 | 3.0 | 1.7 | |
| Ccdc47 | Q5U2X6 | Coiled-Coil Domain Containing 47 | 0.0 | 2.0 | 3.0 | 1.7 | |
| Acyp1 | D4A6X4 | Acylphosphatase 1 | 0.0 | 2.0 | 3.0 | 1.7 | |
| Trappc8 | F1M9W9 | Trafficking Protein Particle Complex 8 | 0.0 | 2.0 | 3.0 | 1.7 | |
| Nup85 | Q4QQS8 | Nucleoporin 85 | 3.0 | 2.0 | 0.0 | 1.7 | |
| Stxbp5l | D3ZU84 | Syntaxin Binding Protein 5-Like | 0.0 | 3.0 | 2.0 | 1.7 | |
| Hectd3 | F1LVZ9 | Hect Domain E3 Ubiquitin Protein Ligase 3 | 0.0 | 3.0 | 2.0 | 1.7 | |
| Rtca | Q68FS8 | Rna Terminal Phosphate Cyclase Domain 1 | 0.0 | 3.0 | 2.0 | 1.7 | |
| Slc12a2 | E9PTX9 | Solute Carrier Family 12 Member 2 | x | 0.0 | 3.0 | 2.0 | 1.7 |
| Hbs1l | Q6AXM7 | Hbs1-Like Translational Gtpase | 0.0 | 2.0 | 3.0 | 1.7 | |
| Pi4k2a | Q99M64 | Phosphatidylinositol 4-Kinase type 2 α | 2.0 | 3.0 | 0.0 | 1.7 | |
| Padi2 | P20717 | Peptidyl Arginine Deiminase 2 | 0.0 | 2.0 | 3.0 | 1.7 | |
| Lypla1 | P70470 | Lysophospholipase I | 0.0 | 2.0 | 2.5 | 1.5 | |
| Gnpnat1 | B1H249 | Glucosamine-Phosphate N-Acetyltransferase 1 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Nub1 | F7ES73 | Negative Regulator of Ubiquitin-Like Proteins 1 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Nolc1 | P41777 | Nucleolar and Coiled-Body Phosphoprotein 1 | 2.0 | 2.0 | 0.0 | 1.3 | |
| Pkp1 | D3ZY51 | Plakophilin 1 | 2.0 | 0.0 | 2.0 | 1.3 | |
| Ddt | P80254 | d-Dopachrome Tautomerase | 0.0 | 2.0 | 2.0 | 1.3 | |
| Ptpn9 | Q641Z2 | Protein Tyrosine Phosphatase, Non-Receptor Type 9 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Exoc8 | O54924 | Exocyst Complex Component 8 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Carm1 | Q4AE70 | Coactivator-Associated Arginine Methyltransferase 1 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Rapgef2 | F1M386 | Rap Guanine Nucleotide Exchange Factor 2 | 0.0 | 2.0 | 2.0 | 1.3 | |
| * Acat1 | P17764 | Acetyl-Coa Acetyltransferase 1 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Dnajc19 | M0R6L8 | Dnaj Heat Shock Protein Family Hsp40 Member C19 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Shoc2 | Q6AYI5 | Shoc2 Leucine-Rich Repeat Scaffold Protein | 0.0 | 2.0 | 2.0 | 1.3 | |
| Nrbp2 | A0A0G2JT23 | Nuclear Receptor Binding Protein 2 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Cul4a | B2RYJ3 | Cullin 4A | 0.0 | 2.0 | 2.0 | 1.3 | |
| Anxa6 | P48037 | Annexin A6 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Fabp3 | P07483 | Fatty Acid Binding Protein 3 | 0.0 | 2.0 | 2.0 | 1.3 | |
| Wasl | O08816 | Wiskott-Aldrich Syndrome-Like | 0.0 | 2.0 | 2.0 | 1.3 | |
Gene name, corresponding UniProt ID, and protein name are indicated for each candidate. TM, Single or multiple predicted transmembrane domains, based on UniProt (04/2020). Only candidate protein partners with MS/MS ratio KCC2/sham >2 in at least two of the three replicates are shown, ranked first by the number of replicates in which they were identified and then by the descending mean MS-MS count in the three replicates.
*Candidates identified in the previous KCC2 interactome (Mahadevan et al., 2017).