Table 1. Survey of joint Raman-OCT systems.
| Ref. | Specifications (Raman) | Specifications (OCT) | Remarks |
|---|---|---|---|
| Patil, C.A., et al. [15] | Lateral res.: 75 µm Axial res.: 600 µm Laser: 785 nm |
Lateral res.: 21 µm Axial res.: 25 µm Source: 1310 ± 30 nm |
• This is the first reported joint RS and OCT system to our knowledge. • Sample arm was shared by Raman and OCT. • Lateral scanning was achieved by galvo mirrors. No axial scanning for RS. |
| Evans, J.W., et al. [16] | Lateral res.: 15 µm Axial res.: NM a Laser: 632.8 nm |
Lateral res.: 18 µm Axial res.: 4.5 µm Source: 855 ± 35 nm |
• Sample arm was shared by Raman and OCT. • Lateral scanning was achieved by moving the sample mounted on a translational stage. No axial scanning for RS. |
| Patil, C.A., et al. [17] | Lateral res.: 15 µm Axial res.: 425 µm Laser: 785 nm |
Lateral res.: 18 µm Axial res.: 11 µm Source: 855 ± 20 nm |
• RS and OCT shared the spectrometer to save cost and size and the sample arm. • Lateral scanning was achieved by galvo mirrors. No axial scanning for RS. |
| Egodage, K.D., et al. [18] | Lateral res.: 100 µm Axial res.: 1000 µm Laser: 785 nm |
Lateral res.: 13 µm Axial res.: 10 µm Source: 1325 ± 100 nm |
• Lateral scanning was achieved by galvo mirrors. No axial scanning for RS. • A probe head was developed to house the sample arm shared by both RS and OCT. |
| Chen, M., et al. [19] | Lateral res.: NM Axial res.: NM Laser: 785 nm |
Lateral res.: NM Axial res.: NM Source: 850 ± 15 nm |
• A wavelength modulated spatially offset RS module was combined with a spectral domain OCT. • Lateral scanning was achieved by galvo mirrors. Depth sensitivity was achieved by varying the spatial offset of the excitation fiber relative to the detection fiber. • Sample arm was shared by Raman and OCT. |
| Varkentin, A., et al. [20], Mazurenka, M., et al. [21] | Lateral res.: NM Axial res.: NM Laser: 532 nm, 7 ns, 20 Hz |
Lateral res.: 13 µm Axial res.: 5.5 µm Source: 1310 nm |
• A probe head housed the sample arm shared by RS and OCT [21]. The Optoacoustics (OA) module had a separate probe [20]. • Lateral scanning was achieved by galvo mirrors. No axial scanning for RS. • The Raman excitation spot matched the field of view of the OCT lens and an iris was used to select the region to be measured so the lateral resolution was expected to be poor. |
| Zakharov, V.P., et al. [22] | Lateral res.: NM Axial res.: NM Laser: 785 nm |
Lateral res.: NM Axial res.: 3.5 µm Source: 840 ± 50 nm |
• Backscattering spectroscopy, RS and OCT were integrated with a fiber probe as the shared sample arm. • No scanning included. |
| Patil, C.A., et al. [23] | Lateral res.: 44 µm Axial res.: 530 µm Laser: 785 nm |
Lateral res.: 25 µm Axial res.: 14 µm Source: 1310 ± 30 nm |
• The join system of RS and OCT in Ref. [15] was integrated with a probe for clinical applications. |
| Wang, J., et al. [24] | Lateral res.: 360 µm Axial res.: 300 µm Laser: 785 nm |
Lateral res.: 12 µm Axial res.: 12 µm Source: 1325 ± 62.5 nm |
• A sideview handheld RS-OCT probe was built. • The sample arms of RS and OCT were separate. |
| Klemes, J., et al. [25] | Lateral res.: NM Axial res.: 27.7 µm Laser: 632.8 nm |
Lateral res.: 3.6 µm Axial res.: 4.3 µm Source: 880 ±31.65 nm |
• Separate CRS and OCT were put together each with a different sample arm. • Two sample arms were mounted on one rotary stage to measure the same region in the lateral dimensions. • A linear stage was used for the axial adjustment of CRS focus. |
a
NM: Not mentioned.