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. 2022 Jan 27;11(1):412–423. doi: 10.1080/22221751.2021.2021806

Figure 4.

Figure 4.

IFN involvement in SARS-CoV-2 interaction with seasonal respiratory viruses. Coinfection assays, as schemed in the upper panel of figure1A, were repeated in the presence or absence of anti-type I and III IFN neutralizing antibodies. A to G. Viral replication, similarly quantified from by RT-qPCR, was compared in the presence (dashed lines) and absence (solid lines) of anti-IFNs antibodies. A: SARS-CoV-2 in single infection. B, C and D: SARS-CoV-2 in IBV, RV and IAV-pre-infected tissues respectively. E, F and G: replication of RV, IAV and IBV in SARS-CoV-2 post-infected tissues, respectively. H. Percentage of ISG15 induction in the presence relative to in absence of anti-IFNs (dashed versus solid bars). In comparison to in the absence of anti-IFNs, statistical significance was calculated with t-tests on the area under the curve from kinetics of virus replication (A, B, C, D, E, F and G, N=3)) and using one-way ANOVA for the percentage of ISG15 induction (H, N = 2). *P < 0.05 and **P < 0.01.