Figure 1.

Structure of the anti-MET antibody showing a close-up of the CDR-L3 and CDR-H3 loop residues. The mutated residues are color-coded according to the sequence representation depicted below. The different variants including the experimentally determined bispecific IgG yields are summarized on the right.¹⁸ Ribbon representation of the X-ray structure of the anti-MET Fab showing that CDR-L3 mutations in this study are distributed over the length of the CDR-L3 loop and in the beginning and the end of the CDR-H3 loop.