Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 17;12:812188. doi: 10.3389/fgene.2021.812188

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Bisserier, Saffran, Brojakowska, Sebastian, Evans, Coleman, Walsh, Mills, Garikipati, Arakelyan, Hadri and Goukassian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pathway enrichment analysis and eXpression2Kinases network. (A) A comprehensive gene set enrichment analysis for the cis- and trans-regulatory target genes of differentially expressed lncRNAs was performed using EnrichR 2021 and the 2021 Kyoto Encyclopedia of Genes and Genomes (KEGG) Human database, Elsevier Pathway Collection, BioPlanet 2019, and the Molecular Signatures Database 2020 (MsigDB). (B) Transcription factor enrichment analysis (left panel) and kinase enrichment (right panel) analyses are shown for all the cis- and trans-regulatory target genes of differentially expressed lncRNAs. (C) The eXpression2Kinases (X2K) network displays the inferred upstream regulatory network predicted to regulate the input list of genes by integrating the results from the TFEA, the network expansion, and the kinase enrichment. Pink nodes represent the top transcription factors predicted to regulate the expression of the input gene list; blue nodes represent the top predicted protein kinases known to phosphorylate the proteins within the expanded subnetwork. Green network edges/links represent kinase-substrate phosphorylation interactions between kinases and their substrates, while grey network edges represent physical protein-protein interactions.