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The group III HHK NikA is composed of six repeated HAMP, histidine kinase (HK), and response regulator (RR) domains. (A) The mutation G693D in P. chrysogenum IFM 57243 is located in the HAMP domain, whereas the mutation T1318P is located in a disordered region. (B) The mutation T960S in P. oxalicum IFM 54751 is located in the HK domain.
