Table 2. Body weight, food and water intake, tissue weights, and plasma and urine parameters of the experimental rats.

	LETO			O-C			O-A			P-value
Initial body weight (g)	460	±	9a	567	±	16b	567	±	15b	<0.001
Final body weight (g)	463	±	9a	539	±	31ab	576	±	17b	0.017
Body weight gain (g)	2.85	±	3.73	-28.4	±	20.1	9.58	±	16.52	0.248
Food intake (g/day)	23.1	±	0.6a	36.3	±	1.3b	29.5	±	0.8c	<0.001
Water intake (mL/day)	29.6	±	1.0a	93.3	±	16.4b	46.2	±	8.5a	0.004
Tissue weights (g/100 g BW)
Kidney	0.490	±	0.008a	0.694	±	0.055b	0.629	±	0.041ab	0.027
Liver	2.39	±	0.02a	3.66	±	0.15b	3.56	±	0.19b	<0.001
Perirenal WAT	2.15	±	0.07a	6.77	±	0.60b	7.55	±	0.26b	<0.001
Plasma parameters (mg/dL)
Creatinine	0.450	±	0.019a	0.270	±	0.015b	0.252	±	0.008b	<0.001
BUN	15.7	±	0.7	18.6	±	1.9	17.1	±	2.4	0.661
Urine parameters
NAG (U/24 h)	0.085	±	0.014a	0.486	±	0.052b	0.411	±	0.024b	<0.001
Albumin (mg/24 h)	0.137	±	0.032a	141	±	46b	66.5	±	11.8ab	0.025

The data show mean ± standard error (SE) (n = 10 for OLETF rats and n = 6 for LETO rats).

^abcDifferent letters in the same column indicate statistical difference, P < 0.05, Tukey’s multiple comparison test. P-values were detected using one-way ANOVA.

BW, body weight; WAT, white adipose tissue; BUN, blood urea nitrogen; NAG, N-acetyl glucosaminidase; LETO, Long-Evans Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima fatty; O-C, OLETF control; O-A, OLETF d-allulose.