TABLE 3.
Plan parameters achieved for scheduled and adapted plans for a representative prostate patient
| Scheduled plan | Adapted plan | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Structure | Goal | Variation | Reference plan | Median (Hodges‐Lehmann) | 95% CI | Median (Hodges‐Lehmann) | 95% CI | Superior plan | Statistical significance |
| CTVp | D 98.0% ≥ 98.0% P: 1 | D 98.0% ≥ 95.0% | 97.5% | 97.7% | (97.3%–98.2%) | 97.9% | (97.6%–98.8%) | Adapted | Fail to reject H 0 |
| CTVp | D mean ≥ 100.0% P: 3 | D mean ≥ 99.0% | 101.2% | 101.3% | (100.9%–101.8%) | 101.5% | (101.3%–101.8%) | Adapted | Reject H 0 |
| CTV_SV Prox | D 98.0% ≥ 98.0% P: 1 | D 98.0% ≥ 95.0% | 99.4% | 98.8% | (97.9%–99.5%) | 99.5% | (98.5%–100.6%) | Adapted | Reject H 0 |
| CTV_SV Distal | D 98.0% ≥ 98.0% P: 1 | D 98.0% ≥ 95.0% | 118.9% | 118.9% | (117.6%–119.6%) | 117.5% | (115.6%–119.3%) | Scheduled | Reject H 0 |
| PTV_60 | D 98.0% ≥ 95.0% P: 1 | D 98.0% ≥ 90.0% | 95.8% | 86.1% | (82.8%–89%) | 95.8% | (94.7%–96.3%) | Adapted | Reject H 0 |
| PTV_60 | D 95.0% ≥ 98.0% P: 1 | D 95.0% ≥ 95.0% | 97.0% | 91.9% | (89.6%–93.9%) | 97.0% | (96.5%–97.6%) | Adapted | Reject H 0 |
| PTV_60 | D min 0.30 cm3 > 100.0% P: 3 | D min 0.30 cm3 ≥ 60.0% | 89.9% | 74.0% | (61.3%–78.4%) | 87.8% | (84.7%–89.7%) | Adapted | Reject H 0 |
| PTV_60 | D 1.0% ≤ 105.0% P: 4 | D 1.0% ≤ 107.0% | 103.0% | 103.4% | (103%–104%) | 103.1% | (102.9%–103.3%) | Adapted | Reject H 0 |
| PTV_60 | D max 0.30 cm3 ≤ 107.0% P: R | D max 0.30 cm3 ≤ 110.0% | 103.5% | 104.1% | (103.6%–104.7%) | 103.7% | (103.5%–103.9%) | Adapted | Reject H 0 |
| PTV_50 | D 98.0% ≥ 95.0% P: 2 | D 98.0% ≥ 90.0% | 114.1% | 102.9% | (99.3%–106.4%) | 111.9% | (109.4%–113.7%) | Adapted | Reject H 0 |
| PTV_50 | D 95.0% ≥ 100.0% P: 3 | D 95.0% ≥ 95.0% | 116.2% | 109.9% | (107.3%–112.2%) | 115.8% | (114.8%–116.5%) | Adapted | Reject H 0 |
| Rectum | V 57.00 Gy < 15.0% P: 2 | V 57.00 Gy ≤ 16.0% | 1.3% | 0.6% | (0.1%–2.2%) | 1.0% | (0.4%–2%) | Scheduled | Reject H 0 |
| Rectum | V 60.00 Gy < 3.0% P: 2 | V 60.00 Gy ≤ 4.0% | 0.0% | 0.0% | (0%–0.4%) | 0.0% | (0%–0%) | Adapted | |
| Rectum | V 28.00 Gy ≤ 58.0% P: 2 | V 28.00 Gy ≤ 60.0% | 31.9% | 33.3% | (28.6%–37.3%) | 32.6% | (29.1%–34.5%) | Adapted | Fail to reject H 0 |
| Rectum | V 18.00 Gy ≤ 60.0% P: 2 | V 18.00 Gy ≤ 65.0% | 56.3% | 62.5% | (57.3%–66.3%) | 55.9% | (53.1%–57.1%) | Adapted | Reject H 0 |
| Rectum | V 52.80 Gy < 30.0% P: 3 | V 52.80 Gy ≤ 30.0% | 4.3% | 2.9% | (0.9%–5.1%) | 4.4% | (2.3%–5.7%) | Scheduled | Reject H 0 |
| Rectum | V 48.60 Gy < 50.0% P: 3 | V 48.60 Gy ≤ 50.0% | 7.3% | 5.3% | (2.3%–8.1%) | 7.7% | (5.2%–9.4%) | Scheduled | Reject H 0 |
| Rectum | V 40.80 Gy < 55.0% P: 3 | V 40.80 Gy ≤ 60.0% | 13.0% | 11.0% | (6.3%–14.3%) | 13.7% | (10.2%–15.8%) | Scheduled | Reject H 0 |
| Bladder | D 0.30 cm3 ≤ 60.00 Gy (3.00 Gy/Fx) P: 1 | D 0.30 cm3 ≤ 61.00 Gy (3.05 Gy/Fx) | 2.94 | 2.96 | (2.94–3) | 2.94 | (2.94–2.98) | Adapted | Reject H 0 |
| Bladder | V 60.00 Gy ≤ 5.0% P: 3 | V 60.00 Gy ≤ 7.0% | 0.0% | 0.0% | (0%–0.1%) | 0.0% | (0%–0.1%) | Adapted | |
| Bladder | V 48.60 Gy ≤ 25.0% P: 3 | V 48.60 Gy ≤ 30.0% | 12.6% | 10.3% | (7.5%–13%) | 12.6% | (8.4%–17.6%) | Scheduled | Reject H 0 |
| Bladder | V 40.80 Gy ≤ 50.0% P: 3 | V 40.80 Gy ≤ 60.0% | 18.7% | 16.3% | (11.5%–21.5%) | 17.9% | (11.8%–24.4%) | Scheduled | Reject H 0 |
| Penile bulb | D 0.30 cm3 < 60.00 Gy (3.00 Gy/Fx) P: 1 | D 0.30 cm3 ≤ 61.00 Gy (3.05 Gy/Fx) | 2.95 | 2.95 | (2.93–2.98) | 2.93 | (2.91–2.94) | Adapted | Reject H 0 |
| Penile bulb | D mean ≤ 48.00 Gy (2.40 Gy/Fx) P: 3 | D mean ≤ 52.50 Gy (2.63 Gy/Fx) | 2.20 | 1.77 | (1.49–1.99) | 1.88 | (1.55–2.22) | Scheduled | Fail to reject H 0 |
| Femur head right | D 0.30 cm3 < 50.00 Gy (2.50 Gy/Fx) P: 3 | D 0.30 cm3 ≤ 52.00 Gy (2.60 Gy/Fx) | 1.23 | 1.33 | (1.28–1.37) | 1.43 | (1.32–1.52) | Scheduled | Reject H 0 |
| Femur head left | D 0.30 cm3 < 50.00 Gy (2.50 Gy/Fx) P: 3 | D 0.30 cm3 ≤ 52.00 Gy (2.60 Gy/Fx) | 1.65 | 1.56 | (1.53–1.6) | 1.50 | (1.39–1.56) | Adapted | Reject H 0 |
| Sigmoid colon | D 0.30 cm3 < 59.00 Gy (2.95 Gy/Fx) P: 1 | D 0.30 cm3 ≤ 60.00 Gy (3.00 Gy/Fx) | 1.36 | 1.93 | (1.5–2.33) | 1.49 | (1.25–2.12) | Adapted | Reject H 0 |
| Sigmoid colon | V 48.60 Gy < 50.0% P: 3 | V 48.60 Gy ≤ 51.0% | 0.0% | 0.2% | (0%–0.9%) | 0.0% | (0%–1.3%) | Adapted | Fail to reject H 0 |
| Sigmoid colon | V 40.80 Gy < 55.0% P: 3 | V 40.80 Gy ≤ 60.0% | 0.0% | 1.0% | (0%–2.7%) | 0.1% | (0%–3.4%) | Adapted | Reject H 0 |
Note: Statistical significance is determined using a Wilcoxon‐signed rank test, the Hodges–Lehmann median is displayed, and Walsh averages were used to determine 95% confidence intervals.