PFGE patterns generated by SmaI digestion of S. pneumoniae serotype 5 isolates recovered from children in Southern Israel during 1994 to 1999. Lanes 1 and 30 contain a lambda ladder; lanes 2 and 29 contain a reference strain, R6, used as a molecular weight marker. Numbers on the left show molecular sizes in kilobases. Lanes 3, 7, 11, 12, 18, 19, and 24 contain NP isolates; lanes 4 to 6, 8 to 10, 13 to 17, 20 to 23, and 25 to 27 contain blood isolates; lane 28 contains a CSF isolate.