PFGE patterns generated by SmaI digestion of S. pneumoniae serotype 6B isolates recovered from children in Southern Israel during 1994 to 1999. Lanes 1 and 30 contain a lambda ladder; lane 2 contains a reference strain, R6, used as a molecular weight marker. Numbers on the left show molecular sizes in kilobases. Lanes 5 to 9, 12 to 13, 15 to 23, 25, and 27 to 29 contain NP isolates; lanes 3, 4, 10, 11, 14, 24, and 26 contain blood isolates.