PFGE patterns generated by SmaI digestion of S. pneumoniae serotype 23F isolates recovered from children in Southern Israel during 1994 to 1999. Lanes 1 and 30 contain a lambda ladder; lanes 2 and 29 contain a reference strain, R6, used as a molecular weight marker. Numbers on the left show molecular sizes in kilobases. Lanes 5, 7, 10 to 16, 18 to 21, and 23 to 28 contain NP isolates; lanes 3, 4, 6, 8, 17, and 22 contain blood isolates; lane 9 contains a CSF isolate.