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. 2022 Feb 1;132(3):e147191. doi: 10.1172/JCI147191

Figure 7. Heparin administration ameliorates AngII-induced cardiac dysfunction in K2KO hearts.

Figure 7

(A) Cardiac function and hypertrophy (n = 5–10). (B) Myocardial hypertrophy (WGA–Alexa Fluor 488 staining), fibrosis (Picrosirius red staining), and capillary density (CD31 immunofluorescence). n = 5–11. (C) Intracardiac microthrombosis (vWF/P-selectin immunofluorescence), NET formation (H3Cit immunofluorescence), and cell death (TUNEL immunofluorescence). Infusion: 4 weeks (A and B) or 1 week (C). P values are from 1-way ANOVA with Tukey’s post hoc test. Representative images from an individual animal (n = 5–11 in each group). Scale bars: 25 μm.