Figure 2. Effect of obesity, independent of insulin resistance, on basal and postprandial plasma glucose and insulin concentrations and insulin kinetics (related to Table 2).

Basal and postprandial plasma glucose (A) and insulin (B) concentrations and insulin secretion (C) and plasma clearance (D) rates in healthy lean participants (n = 8) and participants with obesity (n = 14), who were matched by insulin sensitivity (IS) with the lean participants. Relationships between the plasma glucose concentration and the ISR (E), plasma glucose concentration and plasma insulin concentration (F), ISR and plasma insulin concentration (G), and plasma insulin concentration and ICR (H) before and during the first 30 minutes after glucose ingestion in the same participants. Data are expressed as the mean ± SEM.