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. 2021 Oct 6;66(1):86–95. doi: 10.1165/rcmb.2021-0307OC

Figure 4.

Figure 4.

Antenatal maternal MEx therapy significantly alters preeclamptic amniotic fluid (AF) cytokine and proteomic profiles. An analysis of AF collected from control, PE, or PE + MEx pregnancies at E12 is shown. Data are representative of 3–4 independent experiments with AF pooled from 3–4 pregnant dams per experiment. (A) Quantification of IL-6 protein levels by luminex cytokine analysis. **P < 0.01 and ***P < 0.001. (B) Heatmap of fold changes from pairwise comparisons of Control versus PE or PE versus PE + MEx amniotic proteomic profiles. Targets represent protein changes with a false discovery rate–adjusted P value of <0.05 in addition to Ingenuity Pathway Analysis z-scores of >2 for targets relevant to intrauterine physiology and lung development.