Skip to main content
. 2022 Jan 24;2022:8316335. doi: 10.1155/2022/8316335

Figure 6.

Figure 6

The combination of DHCT+nicotine inhibits tumor growth in HCC mice models. (a) The tumor volume over the time curve was seen in combination treatment, as compared to the nicotine and saline control individual treatment groups. (b) Kaplan–Meier survival curve showed the best overall survival ratio in DHCT+nicotine combination, compared to nicotine only and saline control treatment groups. (c) Comparative real-time PCR analyses showed a significantly reduced Ki-67 expression and induced apoptosis (cl-Caspase-3 and TUNEL-positive cells) mRNA level in combination groups as compared with nicotine and saline counterparts. (d) Representative hematoxylin and eosin (H&E) stained images are shown, and IHC detected the expression of Ki-67 and cl-Caspase-3, and TUNEL apoptotic cells in the tumors from mice were detected. ∗P < 0.05, and ∗∗P < 0.01.