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Vitamin B-12–dependent reactions. Vitamin B-12 serves as a cofactor in 2 metabolic reactions: (A) as methylcobalamin in the conversion of homocysteine and methyltetrahydrofolate to methionine and tetrahydrofolate by methionine synthase and (B) as adenosylcobalamin in the conversion of methylmalonyl CoA to succinyl CoA by methylmalonyl CoA mutase. MMA, methylmalonic acid.
