Skip to main content
. 2021 Oct 11;13(1):16–33. doi: 10.1093/advances/nmab106

FIGURE 10.

FIGURE 10

Effect of short-term folic acid supplementation on serum vitamin B-12 concentration and reticulocyte response in 13 relapsed pernicious anemia patients. Subjects were treated with oral folic acid (18 mg/d) for 5–8 d. Response of serum vitamin B-12 concentrations for each subject (A), the mean serum vitamin B-12 responses (B), and the correlation between % reticulocyte response and % decrease in serum vitamin B-12 (C) are shown. Serum vitamin B-12 concentrations decreased in most subjects after folic acid treatment and the % reticulocyte response was directly correlated with % decrease in serum vitamin B-12. In panel B, different letters indicate statistically significant differences (P = 0.003 by paired t test). In panel C, r and P values based on simple regression. Conversion factor for serum vitamin B-12: pg/mL divided by 1.355 = pmol/L. B12, vitamin B-12; FA, folic acid. Graphs created based on data from reference 53.