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Effect of folic acid supplementation (0.4–1.0 mg/d) for 12–67 d on serum homocysteine and methylmalonic acid in 5 vitamin B-12–deficient patients prior to administration of vitamin B-12. Three of 5 patients exhibited increases in both homocysteine (A) and methylmalonic acid (B) concentrations after folic acid supplementation. Letters (a, b, c, d, and e) represent individual patients. Reproduced from reference 46 with permission.
