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. 2021 Oct 11;13(1):16–33. doi: 10.1093/advances/nmab106

FIGURE 9.

FIGURE 9

Effect of high-dose oral folic acid (5 mg/d) on serum vitamin B-12 in 35 patients with pernicious anemia in remission being treated with intramuscular vitamin B-12 injections (20–30 μg 2×/wk). Subjects were treated with only intramuscular vitamin B-12 for the first 6 mo, then with oral folic acid in addition to the intramuscular vitamin B-12 for the next 6 mo. Response of serum vitamin B-12 concentrations for each subject (A) and the mean serum vitamin B-12 responses (B) are shown. Serum vitamin B-12 concentrations increased after the first 6 mo, but decreased 6 mo after addition of oral folic acid to the treatment regimen. In panel B, different letters indicate statistically significant differences (P < 0.05 by ANOVA followed by Scheffe's test). Conversion factor for serum vitamin B-12: pg/mL divided by 1.355 = pmol/L. B12, vitamin B-12. Graphs created based on data from reference 52.