Table 2.
Genotype distribution, variants features and genotype counts.
| Gene symbol | Alleles | Risk allele | Variant ID | Gene Consequence | Genotype counts | Dominant model (n) | HWE Chi 2 p value |
|---|---|---|---|---|---|---|---|
| PNPLA3 | C>G | G | rs738409 | missense | CC: 31 CG:54 GG:31 |
CC: 31 CG+GG: 85 |
0.45 |
| TM6SF2 | C>T | T | rs58542926 | missense | CC:89 CT:25 TT:2 |
CC: 89 CT+TT: 27 |
0.87 |
| MBOAT7 | C>T | T | rs641738 | TMC4: Missense Variant/MBOAT7: 500B Downstream Variant | CC:44 CT:51 TT:21 |
CC: 44 CT+TT: 72 |
0.36 |
| HSD17B13 | ->A | -/ | rs72613567 | Splicing donor | -/-: 83 -/A: 28 A-INS: 3 |
-/-: 83 -A+AA: 31 * |
0.73 |
| FGF21 | G>A | A | rs838133 | synonymous variant | GG: 61 AG: 43 AA: 12 |
GG: 61 GA+AA: 55 |
0.29 |
HWE: Hardy-Weinberg equilibrium; n=number of participants; PNPLA3: patatin-like phospholipase domain containing 3; TM6SF2: transmembrane 6 superfamily member 2; MBOAT7, Membrane Bound O-Acyltransferase Domain Containing 7; TMC4: Transmembrane Channel-Like Protein 4; HSD17B13: hydroxysteroid 17-beta dehydrogenase 13* two missing genotypes; FGF21: Fibroblast Growth Factor 21.