Table 2.

Correlations Between GSN and Related Genes and Markers of Immune Cells

Description	Gene Markers	None		Purity
		Cor	P-value	Cor	P-value
CD8+ T cell	CD8A	0.246	***	0.244	***
	CD8B	0.117	*	0.117	***
T cell	CD3D	0.179	***	0.17	***
	CD3E	0.22	***	0.217	***
	CD2	0.192	***	0.185	***
B cell	CD19	0.306	***	0.306	***
	CD79A	0.303	***	0.29	***
Monocyte	CD86	0.232	***	0.218	***
	CD115 (CSF1R)	0.453	0e+00	0.439	***
TAM	CCL2	0.363	***	0.345	***
	CD68	0.202	***	0.186	***
	IL10	0.295	***	0.282	***
M1 Macrophage	INOS (NOS2)	−0.091		−0.082	1.12e-01
	IRF5	0.343	***	0.337	***
	COX2(PTGS2)	0.093		0.071	1.67e-01
M2 Macrophage	CD163	0.34	***	0.324	***
	VSIG4	0.355	***	0.355	***
	MS4A4A	0.356	***	0.34	***
Neutrophils	CD66b (CEACAM8)	−0.018	7.18e-01	0	1.00e+00
	CD11b (ITGAM)	0.403	0e+00	0.391	***
	CCR7	0.456	0e+00	0.462	***
Natural killer cell	KIR2DL1	0.005	9.18e-01	0.015	7.66e-01
	KIR2DL3	−0.062	2.08e-01	−0.073	1.55e-01
	KIR2DL4	−0.124	*	−0.13	*
	KIR3DL1	0.047	3.43e-01	0.052	3.17e-01
	KIR3DL2	0.019	6.93e-01	0.03	5.57e-01
	KIR3DL3	−0.092		−0.064	2.14e-01
	KIR2DS4	−0.031	5.35e-01	−0.026	6.08e-01
Dendritic cell	HLA-DPB1	0.263	6e-08	0.251	7.56e-01
	HLA-DQB1	0.145	**	0.129	*
	HLA-DRA	0.154	**	0.141	**
	HLA-DPA1	0.0198	***	0.185	***
	BDCA-1(CD1C)	0.515	***	0.54	***
	BDCA-4(NRP1)	0.542	0e+00	0.518	***
	CD11c (ITGAX)	0.32	***	0.304	***
Th1	T-bet (TBX21)	0.216	***	0.221	***
	STAT4	0.268	***	0.27	***
	STAT1	0.012	8.11e-01	0.024	6.47e-01
	IFN-γ (IFNG)	−0.128	**	−0.124	**
	TNF-α (TNF)	0.08	1.05e-01	0.054	2.91e-01
Th2	GATA3	0.364	2.39e-14	0.376	***
	STAT6	0.319	2.87e-11	0.321	***
	STAT5A	0.418	5.1e-19	0.415	***
	IL13	0.075	1.26e-01	0.089
Tfh	BCL6	0.549	4.65e-34	0.532	***
	IL21	0.027	5.8e-01	0.027	6.02e-01
Th17	STAT3	0.422	0e+00	0.406	***
	IL17A	−0.249	2.86e-07	−0.264	***
Treg	FOXP3	0.203	3.18e-05	0.198	***
	CCR8	0.277	9.61e-09	0.271	***
	STAT5B	0.563	0e+00	0.542	***
	TGFβ (TGFB1)	0.598	1.32e-41	0.595	***
T cell exhaustion	PD-1 (PDCD1)	0.195	6.76e-05	0.195	***
	CTLA4	0.061	2.16e-01	0.049	3.41e-01
	LAG3	0.07	1.53e-01	0.071	1.66e-01
	TIM-3 (HAVCR2)	0.241	7.2e-07	0.233	***
	GZMB	−0.125	*	−0.144	**

Note: P-value significant codes: 0≤***≤0.001≤**≤0.01≤*≤0.05.