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. 2022 Jan 18;12:793197. doi: 10.3389/fimmu.2021.793197

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Copyright © 2022 Conway, Lazarski, Field, Jensen-Wachspress, Lang, Kankate, Durkee-Shock, Kinoshita, Suslovic, Webber, Smith, Cohen, Burbelo, Zhang, Teach, Ibeh, Delaney, DeBiasi, Keller and Bollard

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CST Phenotypes. CSTs were predominantly CD4+ across (A) cohorts and (B) SARS-CoV-2 antigens. (C) CSTs expanded from patients with MIS-C had fewer effector memory and more central memory cells than CSTs from convalescent adults (p < 0.0001). In (A, C) Boxes represent interquartile ranges; lines: median values; whiskers: minimum to maximum. In (B) Boxes represent medians; whiskers: 95% confidence interval. EM, effector memory; CM, central memory; TE, terminal effector. Asterisk (*) signifies p < 0.05.