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. 2021 Sep 10;49(3):847–860. doi: 10.1007/s00259-021-05545-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Characterisation of cRGD-MNPs. a Representative transmission electron microscopy images of MNPs (left) and cRGD-MNPs (right), scale bar: 20 nm. b Zeta potential of MNPs, PEG-MNPs and cRGD-MNPs in aqueous solution. c UV–vis-NIR spectra of MNPs and cRGD-MNPs. d PA spectra of MNPs and cRGD-MNPs. e The photoacoustic signal produced by MNPs and cRGD-MNPs was linear at concentrations from 3.75 to 120 μM. Upper panel: the original PA image. f PA signal intensities of cRGD-MNPs in PBS (pH = 7.4) stored for 1 week. Data are presented as the mean ± SD (n = 3)