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. 2022 Jan 31;12:1678. doi: 10.1038/s41598-022-05694-x

Figure 1.

Figure 1

Gene signature of acquired resistance. (A) Overall scheme of the study. (B) Heatmap of differentially expressed genes between pre-treatment and post-treatment tumor samples in patients who develop acquired resistance (AR) (n = 6 pairs). (C) Gene Set Enrichment Analysis of the AR signature in the entire cohort and post-treatment samples. (D) Gene ontology pathway analysis of the AR signature.