Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 31;12:1641. doi: 10.1038/s41598-022-05580-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

H84T BanLec evaluation in NuSkin mice infected with VZV. NuSkin mice were implanted with a single subcutaneous xenograft of adult human skin and xenografts were inoculated 3–4 weeks later with VZV by intraxenograft injection and scarification. Mice were treated with 50 mg/kg/day H84T BanLec by subcutaneous (sc) or intraperitoneal (ip) routes given 6 h pre-inoculation (−6 HPI) and on DPI 4 and 8 to the Pre-BanLec groups, or by the ip route on DPI 3 and 7 to the Post-BanLec group. Cidofovir was administered daily by ip injection from DPI 3–9. (A) VZV yield was measured by bioluminescence and the fold change calculated as the Total Flux on each day divided by the Total Flux on DPI 2 or 3 (the lowest value for that mouse). Lines represent the average VZV yield per group. (B) VZV yield on DPI 10 was analyzed for statistical significance where each symbol represents one mouse, and the bar is the mean of the group. (*) Signifies statistical significance between the vehicle and a treatment group (p < 0.05, one-way ANOVA, Dunnett’s post hoc test). (C) Mouse weights were measured daily, and the lines show the average weight change for each group from the onset to conclusion of the study. N = 4–12 mice per group.