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. 2022 Jan 31;12:1642. doi: 10.1038/s41598-021-03114-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Modulation of global epidermal 3D melanin density with skin color ITA grade in constitutive pigmentation study. (a) Raw 2PEF intensity images (cyan hot) and Pseudo-FLIM melanin masks (purple) acquired within the basal layer of human forearm skin. High signal intensities appear in white color. (b) Modulation of 3D epidermal melanin density with ITA group and (c) with both ITA group and skin ethnicity. The data are expressed as boxplots with fences. (d) Correlation matrix of the skin colorimetric parameters and multiphoton melanin density estimated in the epidermis and its sub-layers. The data correspond to the Pearson correlation coefficients. An absolute value of the Pearson correlation coefficients between [0.6, 0.8] and [0.8, 1.0] indicate a strong and respectively a very strong correlation. ED (global epidermis), SC - stratum corneum, SC Disj - stratum corneum disjunctum, SC Comp - stratum corneum compactum, LED – living epidermis, SGranu - stratum granulosum, SSpin – stratum spinosum and SBas - stratum basale.