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. 2022 Jan 31;12:1599. doi: 10.1038/s41598-022-05528-w

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Panel (A): MDS Plot comparing all groups. Panel (B): Volcano plot of significant differential gene expression when comparing CD maintained MORF1 and SALF1 males. Panel (C): V Volcano plot of significant differential gene expression when comparing FSD maintained SALF1 and CD maintained SALF1 males. Panels (A–C) N = 6/group. Relative expression of Gnα12 (top) and Plekhh2 (bottom) in punch biopsies of liver samples taken after a 24 h fast. SALF1 CD N = 6; SALF1 FSD N = 6; MORF1 CD N = 7; MORF1 FSD N = 7; *p < 0.05 as compared to all other groups.