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. 2022 Jan 31;12:1659. doi: 10.1038/s41598-022-05660-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Serum activin A levels can be correlated with loss of visceral adipose tissue in PDAC patients. (A) H&E images of visceral adipose tissue from PDAC patients with corresponding activin A levels in ng/ml. Scale bar = 150 µm. (B) Measurement of adipocyte diameter in visceral adipose tissue from PDAC patients. The diameters of adipocytes were measured from several histological sections. 6 sections, 0.761 ng/ml; 14 sections, 2.434 ng/ml; 14 sections, 3.966 ng/ml; 11 sections, 4.160 ng/ml; 10 sections, 7.459 ng/ml; 6 sections, 10.425 ng/ml. Corresponding serum activin A levels are included in ng/ml. (C) Frequency curve of adipocyte diameter in visceral adipose tissue from patients with low serum activin A (0.761 ng/ml, red line), elevated serum activin A (8.984 ng/ml, blue line), and increasingly elevated serum activin A (10.425 ng/ml, black line). The diameters of adipocytes were measured with 6 histological sections each.