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. 2022 Jan 31;12:1659. doi: 10.1038/s41598-022-05660-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Activin A can be correlated with loss of gonadal visceral adipose tissue in an orthotopic implantation model of PDAC. (A) Representative immunohistochemical images of activin A expression in healthy control C57BL/6 J pancreatic tissue and tumor specimens of S2-013 mPDAC. Scale bar = 50 µm. (B) Measurement of serum activin A levels in sham and S2-013 mPDAC. (C) Mass of gonadal fat pad. (D) H&E images of adipose tissue from the gonadal fat pad in sham and S2-013 mPDAC. Scale bar = 150 µm. (E) Measurement of adipocyte diameter in gonadal adipose tissue from sham and S2-013 mPDAC. The diameters of adipocytes were measured from several histological sections (n = 5). The average adipocyte diameter from each animal was marked with a dot. F. Frequency curve of adipocyte diameter in gonadal fat pad of sham mice (dashed line) and S2-013 mPDAC (solid line).