Table 3.
Univariate and multivariate survival models.
| Variable | Univariate | Multivariate (FISH abnormalities only) | Multivariate (all) | |||
|---|---|---|---|---|---|---|
| OS RR (95% CI) | P value | OS RR (95% CI) | P value | OS RR (95% CI) | P value | |
| HR IgH translocations | 2.0 (1.7–2.3) | <0.001 | 1.6 (1.3–1.9) | <0.001 | 1.7 (1.3–2.1) | <0.001 |
| t(11;14) | 1.0 (0.8–1.2) | 0.88 | — | — | — | — |
| Trisomies | 0.8 (0.7–0.9) | 0.003 | 0.9 (0.7–1.0) | 0.08 | — | — |
| MYC rearrangement | 1.5 (1.2–1.9) | <0.001 | 1.5 (1.2–1.9) | 0.002 | 1.3 (1.0–1.8) | 0.06 |
| 1q gain/amplification | 1.8 (1.6–2.2) | <0.001 | 1.6 (1.4–2.0) | <0.001 | 1.4 (1.2–1.8) | <0.001 |
| Monosomy 13 | 1.4 (1.2–1.6) | <0.001 | 1.1 (0.9–1.3) | 0.20 | — | — |
| Del(17p)/monosomy 17 | 2.0 (1.7–2.3) | <0.001 | 1.9 (1.6–2.3) | <0.001 | 1.6 (1.3–2.0) | <0.001 |
| ISS III (vs. ISS I/II) | 1.9 (1.7–2.2) | <0.001 | — | — | 1.7 (1.4–2.0) | <0.001 |
| Elevated LDH | 1.6 (1.4–1.9) | 0.001 | — | — | 1.3 (1.1–1.7) | 0.01 |
Univariate and multivariate analysis including cytogenetic abnormalities, ISS stage and LDH.
Del deletion, HR high-risk, IgH immunoglobulin heavy chain gene locus, ISS international staging system, LDH lactate dehydrogenase, OS overall survival, RR risk ratio. Bolded numbers represent P values < 0.05.