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. 2022 Feb 1;8:10. doi: 10.1038/s41421-022-00373-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Serum NAbs in HCWs with minimal serologic response to a standard two-dose vaccination schedule were analyzed longitudinally at different time points before and after the third dose (red arrow). b Comparison of NAbs between vaccinees with negative or positive serological responses to a standard two-dose vaccination schedule. c Percentages of spike-specific memory B cells in HCWs with a negative serological response to a standard two-dose vaccination schedule. d–f Numbers of spike- or RBD-specific IgG-producing B cells in HCWs with a negative serological response to a standard two-dose vaccination schedule. g, h Numbers of spike-specific IFNγ-producing T cells as detected by ELISpot in HCWs with a negative serological response to a standard two-dose vaccination schedule. i–k Spike-specific T cells, including CD69⁺4-1BB⁺CD8⁺ T cells, OX40⁺4-1BB⁺CD4⁺ T cells, and CXCR5⁺OX40⁺4-1BB⁺ cTFH in HCWs with a negative serological response to a standard two-dose vaccination schedule. Comparisons were done by Wilcoxon rank-sum test in b and one-way ANOVA corrected for multiple comparisons in the rest panels. *P < 0.05, **P < 0.01, ****P < 0.0001; ns, not significant.