FIGURE 2.

Human CNR1 (A) and CNR2 (B) gene structures, their alternatively spliced isoforms, and expression in pancreatic islets. P (green lettering) represents promoters. Exons are open boxes and introns solid lines. The exon numbers are inside the open boxes and intron sizes are marked in kb (kilobase). Downward arrows and capital letters are at the intra-exonal splicing sites. Red letterings, boxes, and arrows represent human specific isoforms, exons, and splicing sites, respectively. The reference of CB1R isoform islet expression (n = 6) is full-length CB1R (CB1R-FL) and the reference of CB2R isoform islet expression (n = 3) is CB2Rb (unpublished data from Diabetes Section, LCI/NIA/NIH).