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MHC-I β-cell restricted antigen (+βAg) or no antigen (−βAg) presentation in medullary epithelium cells (mTEC) inside thymus. AIRE, autoimmune regulator for ectopic expression of β-cell-specific genes. spT cells, single-positive CD8+ or CD4+ T cells. Yellow represents self-reactive and green self-tolerance T cells. Purple serpentine represents CB1R in β-cells and blue serpentine CB2R in immune cells.
