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. 2022 Jan 18;12:809965. doi: 10.3389/fphar.2021.809965

FIGURE 5.

FIGURE 5

Activation of plasma membrane CB2R pathway inhibits NLRP3 inflammasome complex and NFκB activation (red wavy arrows) during inflammation that is initiated by TNFα, ATP, and ceramide, thereby reduces IL-1β secretion.